open access

Vol 68, No 3 (2009)
ORIGINAL ARTICLES
Published online: 2009-05-13
Submitted: 2012-02-06
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Stress-induced changes of interleukin-1β within the limbic system in the rat

E. Badowska-Szalewska, I. Klejbor, J. Sidor-Kaczmarek, T. Cecot, G. Lietzau, J.H. Spodnik, J. Moryś
Folia Morphol 2009;68(3):119-128.

open access

Vol 68, No 3 (2009)
ORIGINAL ARTICLES
Published online: 2009-05-13
Submitted: 2012-02-06

Abstract

The aim of this study was to investigate the influence of two periods of life, namely P28 and P360, on the changes in interleukin-1beta (IL-1β) immunoreactivity (-ir) in the hippocampus (CA1, CA3, DG) and amygdala (central-CeA, medial-MeA) caused by acute and repeated open field (OF), or by forced swim (FS) exposition. Rats were divided into groups: non-stressed, exposed to acute (one-time for 15 min) and chronic stressors (21 days for 15 min daily). We found IL-1β-ir in the control group to be higher in P360 than in P28. In P28, under OF and FS exposure, IL-1β-ir in the CeA remained unaltered but increased in the MeA and in the hippocampus after acute and chronic stress. In P360 no changes were observed in the IL-1β-ir level after acute and chronic stimulation. These data demonstrate that only the levels of IL-1β-ir in juvenile rat brains are affected by FS and OF. Additionally, there was no significant difference between FS and OF stimulation in IL-1β-ir.

Abstract

The aim of this study was to investigate the influence of two periods of life, namely P28 and P360, on the changes in interleukin-1beta (IL-1β) immunoreactivity (-ir) in the hippocampus (CA1, CA3, DG) and amygdala (central-CeA, medial-MeA) caused by acute and repeated open field (OF), or by forced swim (FS) exposition. Rats were divided into groups: non-stressed, exposed to acute (one-time for 15 min) and chronic stressors (21 days for 15 min daily). We found IL-1β-ir in the control group to be higher in P360 than in P28. In P28, under OF and FS exposure, IL-1β-ir in the CeA remained unaltered but increased in the MeA and in the hippocampus after acute and chronic stress. In P360 no changes were observed in the IL-1β-ir level after acute and chronic stimulation. These data demonstrate that only the levels of IL-1β-ir in juvenile rat brains are affected by FS and OF. Additionally, there was no significant difference between FS and OF stimulation in IL-1β-ir.
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Keywords

IL-1β; hippocampus; amygdala; open field; forced swim

About this article
Title

Stress-induced changes of interleukin-1β within the limbic system in the rat

Journal

Folia Morphologica

Issue

Vol 68, No 3 (2009)

Pages

119-128

Published online

2009-05-13

Bibliographic record

Folia Morphol 2009;68(3):119-128.

Keywords

IL-1β
hippocampus
amygdala
open field
forced swim

Authors

E. Badowska-Szalewska
I. Klejbor
J. Sidor-Kaczmarek
T. Cecot
G. Lietzau
J.H. Spodnik
J. Moryś

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