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Vol 68, No 4 (2009)
Original article
Submitted: 2012-02-06
Published online: 2009-11-26
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Controlled cholesterol efflux from the aortic smooth muscle cells triggers microheterogeneity of plasma membrane lipids and induces modification of the mitochondrial topology

C. Tukaj, E. Syta-Książek, A. Zauszkiewicz, K. Drózd, A. Figarski, J.H. Spodnik, M. Woźniak
Folia Morphol 2009;68(4):244-246.

open access

Vol 68, No 4 (2009)
ORIGINAL ARTICLES
Submitted: 2012-02-06
Published online: 2009-11-26

Abstract

It is generally accepted that phospholipids of plasma membrane display lateral segregation into small microdomains commonly known as lipid rafts. Such lateral lipid organization is under the control of cholesterol. Cholesterol depletion evolved by methyl-β-cyclodextrin (MCD) has been found to induce further marked perturbation in lateral lipid organization, evidenced in the high field part of electron paramagnetic resonance spectra of plasma membranes labelled with a spectroscopic probe, namely 5-doxyl-stearic acid (5DOXS). Such perturbation of surface lipid topo-logy has been found to induce distinct changes in the mitochondrial morpho-logy, i.e. switch from filamentous form into small granular form.

Abstract

It is generally accepted that phospholipids of plasma membrane display lateral segregation into small microdomains commonly known as lipid rafts. Such lateral lipid organization is under the control of cholesterol. Cholesterol depletion evolved by methyl-β-cyclodextrin (MCD) has been found to induce further marked perturbation in lateral lipid organization, evidenced in the high field part of electron paramagnetic resonance spectra of plasma membranes labelled with a spectroscopic probe, namely 5-doxyl-stearic acid (5DOXS). Such perturbation of surface lipid topo-logy has been found to induce distinct changes in the mitochondrial morpho-logy, i.e. switch from filamentous form into small granular form.

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Keywords

lipid raft; electron paramagnetic resonance; methyl-β-cyclodextrin; mitochondria

About this article
Title

Controlled cholesterol efflux from the aortic smooth muscle cells triggers microheterogeneity of plasma membrane lipids and induces modification of the mitochondrial topology

Journal

Folia Morphologica

Issue

Vol 68, No 4 (2009)

Article type

Original article

Pages

244-246

Published online

2009-11-26

Page views

545

Article views/downloads

1043

Bibliographic record

Folia Morphol 2009;68(4):244-246.

Keywords

lipid raft
electron paramagnetic resonance
methyl-β-cyclodextrin
mitochondria

Authors

C. Tukaj
E. Syta-Książek
A. Zauszkiewicz
K. Drózd
A. Figarski
J.H. Spodnik
M. Woźniak

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