Vol 69, No 4 (2010)
Original article
Submitted: 2012-02-06
Published online: 2010-12-01
Nuclear maspin expression as a good prognostic factor in human epithelial ovarian carcinoma
M. Sopel, P. Surowiak, I. Berdowska
Folia Morphol 2010;69(4):204-212.
Vol 69, No 4 (2010)
ORIGINAL ARTICLES
Submitted: 2012-02-06
Published online: 2010-12-01
Abstract
Maspin, a protein belonging to the serpin superfamily, seems to exert tumour-suppressive activity. Its significance in ovarian cancer prognosis is currently under
investigation. In the present work, immunocytochemical maspin expression
in 132 invasive epithelial ovarian carcinomas was assessed independently in the
nucleus and cytoplasm, in correlation with histopathological and clinical data.
Positive maspin expression was found in 117 cases: nuclear/cytoplasmatic in 71,
exclusive nuclear in 29, and only cytoplasmatic in 17 cases. Cytoplasmatic maspin
expression was positively correlated with tumour grade (p = 0.000), FIGO stage
(p = 0.002), and distant metastases (p = 0.000) but exhibited no significant
correlation with tumour type (p = 0.078). Nuclear maspin expression showed
negative correlation with tumour grade (p = 0.025), FIGO stage (p = 0.05),
distant metastases (p = 0.001), and cancer remission (p = 0.000) but showed no
significant relationship with the patients’ age (p = 0.948) or cancer subtype
(p = 0.261). Kaplan-Meier survival analysis showed that strong cytoplasmatic
maspin expression was correlated with shorter disease-free survival (p = 0.000)
whereas strong nuclear expression was correlated with longer survival (p = 0.000).
In Cox regression analysis, low nuclear maspin expression (score 2 and 3) remained
a significant independent prognostic factor (p = 0.001) with a relative death risk
of 5.337. The obtained results suggest that maspin expression may be a significant
marker in epithelial ovarian carcinoma prognosis with its nuclear expression
being a good prognostic factor. (Folia Morphol 2010; 69, 4: 20-4212)
Abstract
Maspin, a protein belonging to the serpin superfamily, seems to exert tumour-suppressive activity. Its significance in ovarian cancer prognosis is currently under
investigation. In the present work, immunocytochemical maspin expression
in 132 invasive epithelial ovarian carcinomas was assessed independently in the
nucleus and cytoplasm, in correlation with histopathological and clinical data.
Positive maspin expression was found in 117 cases: nuclear/cytoplasmatic in 71,
exclusive nuclear in 29, and only cytoplasmatic in 17 cases. Cytoplasmatic maspin
expression was positively correlated with tumour grade (p = 0.000), FIGO stage
(p = 0.002), and distant metastases (p = 0.000) but exhibited no significant
correlation with tumour type (p = 0.078). Nuclear maspin expression showed
negative correlation with tumour grade (p = 0.025), FIGO stage (p = 0.05),
distant metastases (p = 0.001), and cancer remission (p = 0.000) but showed no
significant relationship with the patients’ age (p = 0.948) or cancer subtype
(p = 0.261). Kaplan-Meier survival analysis showed that strong cytoplasmatic
maspin expression was correlated with shorter disease-free survival (p = 0.000)
whereas strong nuclear expression was correlated with longer survival (p = 0.000).
In Cox regression analysis, low nuclear maspin expression (score 2 and 3) remained
a significant independent prognostic factor (p = 0.001) with a relative death risk
of 5.337. The obtained results suggest that maspin expression may be a significant
marker in epithelial ovarian carcinoma prognosis with its nuclear expression
being a good prognostic factor. (Folia Morphol 2010; 69, 4: 20-4212)
Keywords
maspin; immunohistochemistry; subcellular localisation; epithelial ovarian carcinoma; prognostic factors
Title
Nuclear maspin expression as a good prognostic factor in human epithelial ovarian carcinoma
Journal
Folia Morphologica
Issue
Vol 69, No 4 (2010)
Article type
Original article
Pages
204-212
Published online
2010-12-01
Page views
512
Article views/downloads
1278
Bibliographic record
Folia Morphol 2010;69(4):204-212.
Keywords
maspin
immunohistochemistry
subcellular localisation
epithelial ovarian carcinoma
prognostic factors
Authors
M. Sopel
P. Surowiak
I. Berdowska