open access

Vol 53, No 1 (2015)
REVIEW
Published online: 2015-04-14
Submitted: 2015-01-08
Accepted: 2015-03-21
Get Citation

Metallothioneins in the lung cancer

Bozena Werynska, Bartosz Pula, Christopher Kobierzycki, Piotr Dziegiel, Marzenna Podhorska-Okolow
DOI: 10.5603/FHC.a2015.0009
·
Pubmed: 25815626
·
Folia Histochem Cytobiol 2015;53(1):1-10.

open access

Vol 53, No 1 (2015)
REVIEW
Published online: 2015-04-14
Submitted: 2015-01-08
Accepted: 2015-03-21

Abstract

Metallothioneins (MTs) are low weight proteins involved in several key cellular processes such as metal ions homeostasis, detoxification and scavenging of free radicals. Four groups of MTs are distinguished: MT-1, MT-2, MT-3 and MT-4. Regardless of the type, MTs are characterized by high content of cysteine, responsible for their biological properties such as binding of relevant zinc and copper ions, as well as toxic ions such as lead and cadmium. MTs were additionally shown to protect cells against oxidative stress damage and participate in differentiation, proliferation and/or apoptosis of normal and cancer cells. Many studies of different neoplasms showed association of elevated MTs levels with occurrence of chemo- and radiotherapy resistance and poor patients’ outcome. In this review, we summarize and discuss the potential mechanism of action of metallotioneins in lung physiology and pathology.

Abstract

Metallothioneins (MTs) are low weight proteins involved in several key cellular processes such as metal ions homeostasis, detoxification and scavenging of free radicals. Four groups of MTs are distinguished: MT-1, MT-2, MT-3 and MT-4. Regardless of the type, MTs are characterized by high content of cysteine, responsible for their biological properties such as binding of relevant zinc and copper ions, as well as toxic ions such as lead and cadmium. MTs were additionally shown to protect cells against oxidative stress damage and participate in differentiation, proliferation and/or apoptosis of normal and cancer cells. Many studies of different neoplasms showed association of elevated MTs levels with occurrence of chemo- and radiotherapy resistance and poor patients’ outcome. In this review, we summarize and discuss the potential mechanism of action of metallotioneins in lung physiology and pathology.
Get Citation

Keywords

metallothionein; lung cancer; non-small cell lung cancer; prognosis; proliferation

About this article
Title

Metallothioneins in the lung cancer

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 53, No 1 (2015)

Pages

1-10

Published online

2015-04-14

DOI

10.5603/FHC.a2015.0009

Pubmed

25815626

Bibliographic record

Folia Histochem Cytobiol 2015;53(1):1-10.

Keywords

metallothionein
lung cancer
non-small cell lung cancer
prognosis
proliferation

Authors

Bozena Werynska
Bartosz Pula
Christopher Kobierzycki
Piotr Dziegiel
Marzenna Podhorska-Okolow

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