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Vol 51, No 2 (2013)
Brief communication
Submitted: 2013-05-31
Accepted: 2013-06-22
Published online: 2013-08-02
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Plasticity of neuropeptidergic neoplasm cells in the primary and metastatic Merkel cell carcinoma

Janusz Godlewski, Anna Kowalczyk, Zygmunt Kozielec, Zenon Pidsudko, Andrzej Kmieć, Kamila Siedlecka-Kroplewska
DOI: 10.5603/FHC.2013.0015
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Folia Histochem Cytobiol 2013;51(2):168-173.

open access

Vol 51, No 2 (2013)
Short Communication
Submitted: 2013-05-31
Accepted: 2013-06-22
Published online: 2013-08-02

Abstract

Merkel cell carcinoma (MCC) is a rare and highly aggressive cutaneous carcinoma with characteristics of neuroendocrine tumor. We performed immunohistochemical analysis to demonstrate the presence of various neuropeptides within cells of MCC resected from a 75-year old woman. The cells of primary tumor of cheek were compared with the cells of regional right submandibular metastatic tumor which was found eight months later. A double- staining IHC for the pan-neuronal marker, PGP 9.5, and selected neuropeptides in the tissue material obtained from both locations was performed. Single multipolar cells in the main mass of primary tumor stained positively for PGP 9.5 and such neuropeptides as GAL, VIP, PACAP, NPY and CGRP. Moreover, we demonstrated for the first time the presence of neuropeptides in metastatic MCC cells. In the metastatic tumor, cells showing the co-localization of PGP-9.5 and neuropeptides were more numerous, mostly of oval shape, and significantly smaller than in the primary tumor. Thus, the progression of MCC may be associated with the acquisition by its cells of new morphological and biological features.

Abstract

Merkel cell carcinoma (MCC) is a rare and highly aggressive cutaneous carcinoma with characteristics of neuroendocrine tumor. We performed immunohistochemical analysis to demonstrate the presence of various neuropeptides within cells of MCC resected from a 75-year old woman. The cells of primary tumor of cheek were compared with the cells of regional right submandibular metastatic tumor which was found eight months later. A double- staining IHC for the pan-neuronal marker, PGP 9.5, and selected neuropeptides in the tissue material obtained from both locations was performed. Single multipolar cells in the main mass of primary tumor stained positively for PGP 9.5 and such neuropeptides as GAL, VIP, PACAP, NPY and CGRP. Moreover, we demonstrated for the first time the presence of neuropeptides in metastatic MCC cells. In the metastatic tumor, cells showing the co-localization of PGP-9.5 and neuropeptides were more numerous, mostly of oval shape, and significantly smaller than in the primary tumor. Thus, the progression of MCC may be associated with the acquisition by its cells of new morphological and biological features.

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Keywords

Merkel cell carcinoma, metastasis, GAL, VIP, PACAP, NPY, CGRP, PGP-9.5.

About this article
Title

Plasticity of neuropeptidergic neoplasm cells in the primary and metastatic Merkel cell carcinoma

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 51, No 2 (2013)

Article type

Brief communication

Pages

168-173

Published online

2013-08-02

Page views

1525

Article views/downloads

1555

DOI

10.5603/FHC.2013.0015

Bibliographic record

Folia Histochem Cytobiol 2013;51(2):168-173.

Keywords

Merkel cell carcinoma
metastasis
GAL
VIP
PACAP
NPY
CGRP
PGP-9.5.

Authors

Janusz Godlewski
Anna Kowalczyk
Zygmunt Kozielec
Zenon Pidsudko
Andrzej Kmieć
Kamila Siedlecka-Kroplewska

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