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E-cadherin expression is more associated with histopathological type of thyroid cancer than with the metastatic potential of tumors
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Abstract
(E-CAD) and the extracapsular extension of tumors, lymph node involvement and the presence of metastasis in
various types of thyroid cancers. Histopathological specimens of 35 benign thyroid lesions and 122 malignant
tumors (papillary, follicular, poorly differentiated and undifferentiated cancers) were analyzed. E-CAD immunostaining
intensity, its subcellular localization, homogeneity within lesion, and the relation of staining intensity
between tumor and surrounding thyroid parenchyma were evaluated. The obtained results show that the variants
of differentiated cancers with a poorer prognosis (i.e. tall cell and follicular variants of papillary cancer and
widely invasive follicular cancers) present reduced intensity of E-CAD expression, its abnormal localization or
heterogeneity of staining more frequently than classical papillary cancers and minimally invasive follicular cancers.
However, the assessment of E-CAD expression does not allow the prediction of extrathyroidal growth of
thyroid cancers.
Abstract
(E-CAD) and the extracapsular extension of tumors, lymph node involvement and the presence of metastasis in
various types of thyroid cancers. Histopathological specimens of 35 benign thyroid lesions and 122 malignant
tumors (papillary, follicular, poorly differentiated and undifferentiated cancers) were analyzed. E-CAD immunostaining
intensity, its subcellular localization, homogeneity within lesion, and the relation of staining intensity
between tumor and surrounding thyroid parenchyma were evaluated. The obtained results show that the variants
of differentiated cancers with a poorer prognosis (i.e. tall cell and follicular variants of papillary cancer and
widely invasive follicular cancers) present reduced intensity of E-CAD expression, its abnormal localization or
heterogeneity of staining more frequently than classical papillary cancers and minimally invasive follicular cancers.
However, the assessment of E-CAD expression does not allow the prediction of extrathyroidal growth of
thyroid cancers.
Title
E-cadherin expression is more associated with histopathological type of thyroid cancer than with the metastatic potential of tumors
Journal
Folia Histochemica et Cytobiologica
Issue
Article type
Original paper
Pages
519-526
Published online
2012-12-23
Page views
1842
Article views/downloads
2500
DOI
10.5603/FHC.2012.0073
Bibliographic record
Folia Histochem Cytobiol 2012;50(4):519-526.
Authors
Dorota Slowinska-Klencka
Stanislaw Sporny
Olga Stasikowska-Kanicka
Bozena Popowicz
Mariusz Klencki