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Melanoma and other malignant skin cancers in psoriatic patients treated with phototherapy. Role of the p16 protein in psoriasis
open access
Abstract
Recently, the potential risk of malignant skin cancer development in psoriatic patients has been highlighted. It seems that some pathogenetic factors in psoriasis could predispose to a malignant transformation. So far, the relationship between the therapeutic schemes in psoriasis and possible neoplastic transformation has not been clearly explained. The phototherapy is considered a very effective therapeutic method in psoriasis, however, the pathogenesis of some malignancies is associated with the exposure to UV radiation.
One of the defence mechanisms that protect the cells from damaging and mutagenic factors, such as UV radiation, seems to be the p16 protein. Moreover, in recent years, the altered expression of the p16 protein in the diseases not related to malignant transformation, including psoriasis, has been observed. The new hypothesis suggesting a participation of the p16 protein in psoriatic plaque formation has appeared.
Abstract
Recently, the potential risk of malignant skin cancer development in psoriatic patients has been highlighted. It seems that some pathogenetic factors in psoriasis could predispose to a malignant transformation. So far, the relationship between the therapeutic schemes in psoriasis and possible neoplastic transformation has not been clearly explained. The phototherapy is considered a very effective therapeutic method in psoriasis, however, the pathogenesis of some malignancies is associated with the exposure to UV radiation.
One of the defence mechanisms that protect the cells from damaging and mutagenic factors, such as UV radiation, seems to be the p16 protein. Moreover, in recent years, the altered expression of the p16 protein in the diseases not related to malignant transformation, including psoriasis, has been observed. The new hypothesis suggesting a participation of the p16 protein in psoriatic plaque formation has appeared.
About this articleTitle
Melanoma and other malignant skin cancers in psoriatic patients treated with phototherapy. Role of the p16 protein in psoriasis
Journal
Folia Histochemica et Cytobiologica
Issue
Article type
Review paper
Pages
491-496
Published online
2012-12-23
Page views
3527
Article views/downloads
3948
DOI
10.5603/FHC.2012.0069
Bibliographic record
Folia Histochem Cytobiol 2012;50(4):491-496.
Authors
Anna Szponar-Bojda
Aldona Pietrzak
Agnieszka Agnieszka Sobczyńska-Tomaszewska
Adam Borzęcki
Andrzej Kurylcio
Wojciech Polkowski
Anna Poluha
Grażyna Chodorowska
