Vol 50, No 3 (2012)
Original paper
Published online: 2012-10-08
Total antioxidant status (TAS) in childhood cancer survivors
DOI: 10.5603/FHC.2012.0065
Folia Histochem Cytobiol 2012;50(3):468-472.
Abstract
Total antioxidant status (TAS), and the influence of treatment and correlation between TAS and parameters
involved in metabolic syndrome (MS) in pediatric cancer survivors were evaluated. One hundred children
and adolescents were studied. Twenty-five survivors received radiotherapy, 12 were obese or overweight.
Additionally, we analyzed TAS in eight children with acute lymphoblastic leukemia (ALL) at diagnosis and
during treatment after remission induction. The control group consisted of 22 healthy children. Serum concentrations
of TAS, glucose, cholesterol, HDL-cholesterol, triglycerides, fibrinogen and insulin were measured. In
cancer survivors, independently of diagnosis and kind of treatment (radiotherapy anthracyclines administration),
the mean serum TAS did not differ significantly from the control group. No correlations were observed
with age at the time of diagnosis or interval after the end of treatment. TAS values did not correlate with traits of
the metabolic syndrome. In a group of eight patients with ALL at diagnosis and after induction of remission,
TAS values were lower than in the control and cancer survivor groups. Antioxidant status was not found to be
deteriorated in children after anticancer treatment, irrespective of diagnosis or kind of treatment, which might
indicate sufficient antioxidant prevention. However, the possibility of the development of MS and cardiovascular
disease in adulthood indicates the need for future studies.
involved in metabolic syndrome (MS) in pediatric cancer survivors were evaluated. One hundred children
and adolescents were studied. Twenty-five survivors received radiotherapy, 12 were obese or overweight.
Additionally, we analyzed TAS in eight children with acute lymphoblastic leukemia (ALL) at diagnosis and
during treatment after remission induction. The control group consisted of 22 healthy children. Serum concentrations
of TAS, glucose, cholesterol, HDL-cholesterol, triglycerides, fibrinogen and insulin were measured. In
cancer survivors, independently of diagnosis and kind of treatment (radiotherapy anthracyclines administration),
the mean serum TAS did not differ significantly from the control group. No correlations were observed
with age at the time of diagnosis or interval after the end of treatment. TAS values did not correlate with traits of
the metabolic syndrome. In a group of eight patients with ALL at diagnosis and after induction of remission,
TAS values were lower than in the control and cancer survivor groups. Antioxidant status was not found to be
deteriorated in children after anticancer treatment, irrespective of diagnosis or kind of treatment, which might
indicate sufficient antioxidant prevention. However, the possibility of the development of MS and cardiovascular
disease in adulthood indicates the need for future studies.
