open access

Vol 50, No 2 (2012)
Short Communication
Submitted: 2012-07-05
Accepted: 2012-07-05
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Occurrence of the aacA4 gene among multidrug resistant strains of Pseudomonas aeruginosa isolated from bronchial secretions obtained from the Intensive Therapy Unit at University Hospital in Bialystok, Poland

Paweł Sacha, Jadwiga Jaworowska, Dominika Ojdana, Piotr Wieczorek, Sławomir Czaban, Elżbieta Tryniszewska
DOI: 10.5603/FHC.2012.0043
·
Folia Histochem Cytobiol 2012;50(2):322-324.

open access

Vol 50, No 2 (2012)
Short Communication
Submitted: 2012-07-05
Accepted: 2012-07-05

Abstract

The aim of this study was to investigate the prevalence of the aacA4 gene in a population of multidrug resistant strains of P. aeruginosa isolated from bronchial secretions obtained from the Intensive Therapy Unit (ITU). Twelve MDR isolates were tested for antibiotic susceptibility and the presence of the aacA4 gene. In this study, 58.3% of the strains contained (6’)-Ib’ aminoglycoside acetyltransferase gene. All of the studied strains (aacA4-positive and aacA4-negative) were susceptible only to colistine (100%). Among other antibiotics, the lowest resistance rates were those shown against ceftazidime (14.3% to 20%) and imipenem (28.6% to 40%). Our studies frequently revealed the presence of the aacA4 gene as a factor responsible for resistance; it is probable that other mechanisms of resistance to aminoglycoside antibiotics also occurred.

Abstract

The aim of this study was to investigate the prevalence of the aacA4 gene in a population of multidrug resistant strains of P. aeruginosa isolated from bronchial secretions obtained from the Intensive Therapy Unit (ITU). Twelve MDR isolates were tested for antibiotic susceptibility and the presence of the aacA4 gene. In this study, 58.3% of the strains contained (6’)-Ib’ aminoglycoside acetyltransferase gene. All of the studied strains (aacA4-positive and aacA4-negative) were susceptible only to colistine (100%). Among other antibiotics, the lowest resistance rates were those shown against ceftazidime (14.3% to 20%) and imipenem (28.6% to 40%). Our studies frequently revealed the presence of the aacA4 gene as a factor responsible for resistance; it is probable that other mechanisms of resistance to aminoglycoside antibiotics also occurred.
Get Citation

Keywords

Pseudomonas aeruginosa; aacA4 gene; antimicrobial susceptibility

About this article
Title

Occurrence of the aacA4 gene among multidrug resistant strains of Pseudomonas aeruginosa isolated from bronchial secretions obtained from the Intensive Therapy Unit at University Hospital in Bialystok, Poland

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 50, No 2 (2012)

Pages

322-324

DOI

10.5603/FHC.2012.0043

Bibliographic record

Folia Histochem Cytobiol 2012;50(2):322-324.

Keywords

Pseudomonas aeruginosa
aacA4 gene
antimicrobial susceptibility

Authors

Paweł Sacha
Jadwiga Jaworowska
Dominika Ojdana
Piotr Wieczorek
Sławomir Czaban
Elżbieta Tryniszewska

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