open access

Vol 50, No 2 (2012)
Original paper
Submitted: 2012-02-03
Accepted: 2012-02-03
Published online: 2012-07-05
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Cytometric evaluation of transferrin receptor 1 (CD71) in childhood acute lymphoblastic leukemia

Anna Płoszyńska, Katarzyna Ruckemann-Dziurdzińska, Agnieszka Jóźwik, Anna Mikosik, Katarzyna Lisowska, Anna Balcerska, Jacek M. Witkowski
DOI: 10.5603/FHC.2012.0040
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Folia Histochem Cytobiol 2012;50(2):304-311.

open access

Vol 50, No 2 (2012)
ORIGINAL PAPERS
Submitted: 2012-02-03
Accepted: 2012-02-03
Published online: 2012-07-05

Abstract

Transferrin receptor 1 (CD71) is a transmembrane glycoprotein responsible for cellular iron uptake. Higher expression of CD71 has been identified as a negative prognostic marker for numerous solid tumor types and for some lymphomas. The aim of this study was to evaluate CD71 expression on acute lymphoblastic leukemia (ALL) cells and to follow its possible clinical correlations. Sixty one patients, aged 1–17 years and diagnosed with ALL, were enrolled in the study. CD71 expression was analyzed on the bone marrow blastic cells by flow cytometry. CD71 expression on the  eukemic blasts was diversified; in most patients, all blastic cells showed expression of CD71, but levels of expression varied. CD71 expression was statistically higher on T-lineage leukemias. Within the B lineage ALL, a significant difference in CD71 expression existed between precursor B ALL and mature B-ALL, which showed higher CD71 expression. CD71 expression positively correlated with Hgb concentration at diagnosis. Initial risk group assessment and therapy response were not correlated with CD71 expression, although disease free and overall survival times tended to be shorter in patients with B-lineage leukemias with initial high CD71 expression.

Abstract

Transferrin receptor 1 (CD71) is a transmembrane glycoprotein responsible for cellular iron uptake. Higher expression of CD71 has been identified as a negative prognostic marker for numerous solid tumor types and for some lymphomas. The aim of this study was to evaluate CD71 expression on acute lymphoblastic leukemia (ALL) cells and to follow its possible clinical correlations. Sixty one patients, aged 1–17 years and diagnosed with ALL, were enrolled in the study. CD71 expression was analyzed on the bone marrow blastic cells by flow cytometry. CD71 expression on the  eukemic blasts was diversified; in most patients, all blastic cells showed expression of CD71, but levels of expression varied. CD71 expression was statistically higher on T-lineage leukemias. Within the B lineage ALL, a significant difference in CD71 expression existed between precursor B ALL and mature B-ALL, which showed higher CD71 expression. CD71 expression positively correlated with Hgb concentration at diagnosis. Initial risk group assessment and therapy response were not correlated with CD71 expression, although disease free and overall survival times tended to be shorter in patients with B-lineage leukemias with initial high CD71 expression.
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Keywords

transferrin receptor 1; CD71; acute lymphoblastic leukemia

About this article
Title

Cytometric evaluation of transferrin receptor 1 (CD71) in childhood acute lymphoblastic leukemia

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 50, No 2 (2012)

Article type

Original paper

Pages

304-311

Published online

2012-07-05

Page views

2755

Article views/downloads

2820

DOI

10.5603/FHC.2012.0040

Bibliographic record

Folia Histochem Cytobiol 2012;50(2):304-311.

Keywords

transferrin receptor 1
CD71
acute lymphoblastic leukemia

Authors

Anna Płoszyńska
Katarzyna Ruckemann-Dziurdzińska
Agnieszka Jóźwik
Anna Mikosik
Katarzyna Lisowska
Anna Balcerska
Jacek M. Witkowski

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