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Vol 50, No 2 (2012)
Original paper
Submitted: 2012-01-19
Accepted: 2012-01-19
Published online: 2012-07-04
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Pretreatment plasma levels and diagnostic utility of hematopoietic cytokines in cervical cancer or cervical intraepithelial neoplasia patients

Sławomir Ławicki, Grażyna E. Będkowska, Ewa Gacuta-Szumarska, Paweł Knapp, Maciej Szmitkowski
DOI: 10.5603/FHC.2012.0030
·
Folia Histochem Cytobiol 2012;50(2):213-219.

open access

Vol 50, No 2 (2012)
ORIGINAL PAPERS
Submitted: 2012-01-19
Accepted: 2012-01-19
Published online: 2012-07-04

Abstract

In this study, we compared plasma levels and the diagnostic utility of hematopoietic growth factors (HGFs) with SCC-Ag in cervical cancer patients in relation to control groups and cervical intraepithelial neoplasia (CIN) patients and healthy subjects. Pretreatment plasma levels of HGFs (SCF, GM-CSF, G-CSF and M-CSF) were determined by the use of immunoenzyme assay (ELISA), and SCC-Ag by chemiluminescent microparticle immunoassay (CMIA). Significantly different concentrations of GM-CSF, G-CSF and M-CSF were observed in the group of patients with cervical cancer and CIN compared to the healthy controls. Significant differences in plasma levels of GM-CSF and M-CSF between cervical cancer and benign lesions patients were also found. The HGFs and SCC-Ag diagnostic specificities received high values. The diagnostic sensitivity and the predictive value of a positive and negative test result were higher for M-CSF than for antigen SCC in the cancer group. The M-CSF area under the ROC curve (AUC) was the largest from hematopoietic cytokines and SCC-Ag. These results suggest the potential utility of M-CSF as a good candidate for a marker of cervical cancer as well as benign lesions of this organ (CIN).

Abstract

In this study, we compared plasma levels and the diagnostic utility of hematopoietic growth factors (HGFs) with SCC-Ag in cervical cancer patients in relation to control groups and cervical intraepithelial neoplasia (CIN) patients and healthy subjects. Pretreatment plasma levels of HGFs (SCF, GM-CSF, G-CSF and M-CSF) were determined by the use of immunoenzyme assay (ELISA), and SCC-Ag by chemiluminescent microparticle immunoassay (CMIA). Significantly different concentrations of GM-CSF, G-CSF and M-CSF were observed in the group of patients with cervical cancer and CIN compared to the healthy controls. Significant differences in plasma levels of GM-CSF and M-CSF between cervical cancer and benign lesions patients were also found. The HGFs and SCC-Ag diagnostic specificities received high values. The diagnostic sensitivity and the predictive value of a positive and negative test result were higher for M-CSF than for antigen SCC in the cancer group. The M-CSF area under the ROC curve (AUC) was the largest from hematopoietic cytokines and SCC-Ag. These results suggest the potential utility of M-CSF as a good candidate for a marker of cervical cancer as well as benign lesions of this organ (CIN).

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Keywords

cervical cancer; HGFs; SCC-Ag; tumor markers

About this article
Title

Pretreatment plasma levels and diagnostic utility of hematopoietic cytokines in cervical cancer or cervical intraepithelial neoplasia patients

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 50, No 2 (2012)

Article type

Original paper

Pages

213-219

Published online

2012-07-04

Page views

2295

Article views/downloads

2400

DOI

10.5603/FHC.2012.0030

Bibliographic record

Folia Histochem Cytobiol 2012;50(2):213-219.

Keywords

cervical cancer
HGFs
SCC-Ag
tumor markers

Authors

Sławomir Ławicki
Grażyna E. Będkowska
Ewa Gacuta-Szumarska
Paweł Knapp
Maciej Szmitkowski

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