Vol 50, No 2 (2012)
Original paper
Submitted: 2012-01-19
Accepted: 2012-01-19
Published online: 2012-07-05
The concentrations of soluble HLA-G protein are elevated during mid-gestation and decreased in pre-eclampsia
Dorota Darmochwal-Kolarz, Bogdan Kolarz, Jacek Rolinski, Bozena Leszczynska-Gorzelak, Jan Oleszczuk
DOI: 10.5603/FHC.2012.0023
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Folia Histochem Cytobiol 2012;50(2):286-291.
Vol 50, No 2 (2012)
ORIGINAL PAPERS
Submitted: 2012-01-19
Accepted: 2012-01-19
Published online: 2012-07-05
Abstract
The aim of our study was to investigate the dynamics of the alterations of soluble human leukocyte antigen-G (sHLA-G) concentrations in sera of healthy non-pregnant women, as well as healthy pregnant women and patients with pre-eclampsia. Thirty five patients with pre-eclampsia, 52 healthy pregnant women, and 24 healthy non-pregnant women were included in the study. Sera concentrations of sHLA-G protein were determined using the immunoenzymatic ELISA method. Statistical analysis was performed using ANOVA and Mann–Whitney U tests. The concentrations of sHLA-G protein in sera of pregnant women in the first, as well as the second and third, trimesters of normal pregnancy were significantly higher in comparison with healthy nonpregnant women. The sera concentrations of sHLA-G in pregnant women in the second trimester of pregnancy were significantly higher compared to the first and third trimesters. The concentrations of sHLA-G in sera of patients with pre-eclampsia were significantly lower than in pregnant women in the third trimester of physiological pregnancy. The results of our study suggest that normal physiological pregnancy is associated with elevated sera concentrations of sHLA-G molecule. The increased concentrations of sHLA-G molecule in mid-gestation could suggest a role for the protein in the second phase of a physiological invasion of extravillous cytotrophoblast to spiral arteries. Furthermore, the results could suggest a role for the decreased sera concentrations of sHLA-G in the pathogenesis of pre-eclampsia.
Abstract
The aim of our study was to investigate the dynamics of the alterations of soluble human leukocyte antigen-G (sHLA-G) concentrations in sera of healthy non-pregnant women, as well as healthy pregnant women and patients with pre-eclampsia. Thirty five patients with pre-eclampsia, 52 healthy pregnant women, and 24 healthy non-pregnant women were included in the study. Sera concentrations of sHLA-G protein were determined using the immunoenzymatic ELISA method. Statistical analysis was performed using ANOVA and Mann–Whitney U tests. The concentrations of sHLA-G protein in sera of pregnant women in the first, as well as the second and third, trimesters of normal pregnancy were significantly higher in comparison with healthy nonpregnant women. The sera concentrations of sHLA-G in pregnant women in the second trimester of pregnancy were significantly higher compared to the first and third trimesters. The concentrations of sHLA-G in sera of patients with pre-eclampsia were significantly lower than in pregnant women in the third trimester of physiological pregnancy. The results of our study suggest that normal physiological pregnancy is associated with elevated sera concentrations of sHLA-G molecule. The increased concentrations of sHLA-G molecule in mid-gestation could suggest a role for the protein in the second phase of a physiological invasion of extravillous cytotrophoblast to spiral arteries. Furthermore, the results could suggest a role for the decreased sera concentrations of sHLA-G in the pathogenesis of pre-eclampsia.
Keywords
pregnancy; pre-eclampsia; sHLA-G
Title
The concentrations of soluble HLA-G protein are elevated during mid-gestation and decreased in pre-eclampsia
Journal
Folia Histochemica et Cytobiologica
Issue
Vol 50, No 2 (2012)
Article type
Original paper
Pages
286-291
Published online
2012-07-05
Page views
2379
Article views/downloads
2351
DOI
10.5603/FHC.2012.0023
Bibliographic record
Folia Histochem Cytobiol 2012;50(2):286-291.
Keywords
pregnancy
pre-eclampsia
sHLA-G
Authors
Dorota Darmochwal-Kolarz
Bogdan Kolarz
Jacek Rolinski
Bozena Leszczynska-Gorzelak
Jan Oleszczuk
About this article