Vol 50, No 1 (2012)
Review paper
Published online: 2012-04-25
Role of cathepsin A and cathepsin C in the regulation of glycosidase activity
DOI: 10.5603/FHC.2012.0003
Folia Histochem Cytobiol 2012;50(1):20-24.
Abstract
Increased tissue activity of cathepsin A and cathepsin C can be observed in many pathological conditions. It is associated with an enhanced degradation of glycosaminoglycans, proteoglycans, and glycoproteins, and results in their decreased tissue content. Cathepsin C releases the glycosidases from complexes formed with cathepsin A, and reinstates their activity. In this review a current state of knowledge is presented concerning the regulation of selected glycosidases activity by cathepsin A (EC 3.4.16.1) and C (EC 3.4.14.1).
Keywords: cathepsin Alysosomal carboxypeptidase Acathepsin Cdipeptydyl peptidase Iglycosidase activity
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