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Vol 49, No 4 (2011)
Original paper
Submitted: 2012-01-16
Published online: 2012-01-16
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Distribution and chemical coding pattern of somatostatin immunoreactivity in the dorsal striatum of the guinea pig

Barbara Wasilewska, Anna Robak, Maciej Równiak, Krystyna Bogus-Nowakowska, Janusz Najdzion, Witold Żakowski, Mariusz Majewski
DOI: 10.5603/FHC.2011.0093
·
Folia Histochem Cytobiol 2011;49(4):690-699.

open access

Vol 49, No 4 (2011)
ORIGINAL PAPERS
Submitted: 2012-01-16
Published online: 2012-01-16

Abstract

The present study provides a detailed description of somatostatin (SOM) distribution and the colocalization pattern of SOM, neuropeptide Y (NPY) and nitric oxide synthase (NOS) in the dorsal striatum (caudate-putamen complex) of the guinea pig. Within the dorsal striatum, SOM is found in a population of medium-sized aspiny interneurons. We found that 97% of all SOM-IR neurons expressed NPY simultaneously, while 98% of all NPY-ergic perikarya was simultaneously SOM-IR. On the other hand, while 98% of all SOM-IR cells were simultaneously NOS-IR, only 91% of all NOS-containing neurons exhibited SOM-immunoreactivity. Irrespective of their chemical coding, both types of SOM-IR neurons were scattered throughout the dorsal striatum, sometimes in the form of small, loosely arranged clusters of 2–4 cells. While SOM-IR and NPY-IR nerve fibers were present in all of the studied regions, they were more numerous in the ventro-medial part of the studied structure, with the exception of its caudal portion, where SOM-IR and NPY-IR fibers additionally formed a dense network in the part corresponding to the caudate nucleus. A low expression of staining for NOS-IR fibers was seen throughout the entire dorsal striatum. In some fibers, SOM and NPY were co-expressed. Fibers expressing both SOM and NOS were not found. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 4, pp. 690–699)

Abstract

The present study provides a detailed description of somatostatin (SOM) distribution and the colocalization pattern of SOM, neuropeptide Y (NPY) and nitric oxide synthase (NOS) in the dorsal striatum (caudate-putamen complex) of the guinea pig. Within the dorsal striatum, SOM is found in a population of medium-sized aspiny interneurons. We found that 97% of all SOM-IR neurons expressed NPY simultaneously, while 98% of all NPY-ergic perikarya was simultaneously SOM-IR. On the other hand, while 98% of all SOM-IR cells were simultaneously NOS-IR, only 91% of all NOS-containing neurons exhibited SOM-immunoreactivity. Irrespective of their chemical coding, both types of SOM-IR neurons were scattered throughout the dorsal striatum, sometimes in the form of small, loosely arranged clusters of 2–4 cells. While SOM-IR and NPY-IR nerve fibers were present in all of the studied regions, they were more numerous in the ventro-medial part of the studied structure, with the exception of its caudal portion, where SOM-IR and NPY-IR fibers additionally formed a dense network in the part corresponding to the caudate nucleus. A low expression of staining for NOS-IR fibers was seen throughout the entire dorsal striatum. In some fibers, SOM and NPY were co-expressed. Fibers expressing both SOM and NOS were not found. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 4, pp. 690–699)

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Keywords

somatostatin; nitric oxide synthase; neuropeptide Y; dorsal striatum; guinea pig

About this article
Title

Distribution and chemical coding pattern of somatostatin immunoreactivity in the dorsal striatum of the guinea pig

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 49, No 4 (2011)

Article type

Original paper

Pages

690-699

Published online

2012-01-16

Page views

1409

Article views/downloads

1828

DOI

10.5603/FHC.2011.0093

Bibliographic record

Folia Histochem Cytobiol 2011;49(4):690-699.

Keywords

somatostatin
nitric oxide synthase
neuropeptide Y
dorsal striatum
guinea pig

Authors

Barbara Wasilewska
Anna Robak
Maciej Równiak
Krystyna Bogus-Nowakowska
Janusz Najdzion
Witold Żakowski
Mariusz Majewski

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