Multimedialna platforma wiedzy medycznej Internetowa Księgarnia Medyczna Kalendarium Konferencji
Folia Histochemica et Cytobiologica
MENU
Shortcuts Submit an article Author Guidelines Ahead of Print Reviewers 2023 Editorial Board

open access

Vol 49, No 4 (2011)
Review paper
Submitted: 2012-01-16
Published online: 2012-01-16
View PDF Download PDF file
Get Citation

Cryoglobulinemic glomerulonephritis — lessons from animal models

Jolanta Kowalewska
DOI: 10.5603/FHC.2011.0077
·
Folia Histochem Cytobiol 2011;49(4):537-546.

open access

Vol 49, No 4 (2011)
REVIEW
Submitted: 2012-01-16
Published online: 2012-01-16

Abstract

In humans cryoglobulinemic glomerulonephritis (CGGN) may develop in the course of systemic cryoglobulinemia (CG) and is often associated with hepatitis C virus infection. It is believed that the glomerular injury in CG results from the deposition of immune complexes, but exact sequence of events in this process is unknown. Experimental models of CGGN provide an important tool to study pathogenesis of this type injury. This review describes two mouse models of CGGN and their use in understanding the role of various molecules involved in regulation of inflammatory and fibrosis pathways, such as complement components, Fc receptors, growth factors, and others; as well as illustrates their role in testing novel approaches of treatment in this type of renal injury. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 4, pp. 537–546)

Abstract

In humans cryoglobulinemic glomerulonephritis (CGGN) may develop in the course of systemic cryoglobulinemia (CG) and is often associated with hepatitis C virus infection. It is believed that the glomerular injury in CG results from the deposition of immune complexes, but exact sequence of events in this process is unknown. Experimental models of CGGN provide an important tool to study pathogenesis of this type injury. This review describes two mouse models of CGGN and their use in understanding the role of various molecules involved in regulation of inflammatory and fibrosis pathways, such as complement components, Fc receptors, growth factors, and others; as well as illustrates their role in testing novel approaches of treatment in this type of renal injury. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 4, pp. 537–546)

Full Text:

View PDF Download PDF file
Get Citation

Keywords

cryoglobulinemia; glomerulonephritis; animal models

About this article
Title

Cryoglobulinemic glomerulonephritis — lessons from animal models

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 49, No 4 (2011)

Article type

Review paper

Pages

537-546

Published online

2012-01-16

Page views

2210

Article views/downloads

2950

DOI

10.5603/FHC.2011.0077

Bibliographic record

Folia Histochem Cytobiol 2011;49(4):537-546.

Keywords

cryoglobulinemia
glomerulonephritis
animal models

Authors

Jolanta Kowalewska

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Group sp z o.o., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl