Vol 49, No 4 (2011)
Original paper
Published online: 2012-01-16
Control of active B and L cathepsins in tissues of colorectal cancer using cystatins isolated from chicken egg proteins: in vitro studies
DOI: 10.5603/FHC.2011.0075
Folia Histochem Cytobiol 2011;49(4):670-676.
Abstract
The activity of cysteine peptidases (cathepsins B and L) was estimated in homogenates of tissues sampled
during surgery from 60 patients operated due to colorectal tumors. The results were compared to those obtained
using tissues in which histopathology disclosed no tumorous cells, obtained from 20 patients of the same group,
treated as a control. Activity of the enzymes was inhibited using cysteine peptidase inhibitors isolated from chicken
egg proteins. Application of the inhibitors was found to inhibit activity of the enzymes which play a key role in
tumor development. It is suggested that in future the inhibitors may provide a component of new generation drugs
in the so-called inhibitor therapy. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 4, pp. 670–676)
Keywords: large intestinecystatinscathepsins
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