Vol 49, No 3 (2011)
Original paper
Submitted: 2012-01-05
Published online: 2011-10-28
Influence of myocardial infarction on changes in the expression of angiotensin type 1 receptor in the rat prostate
Agnieszka W. Piastowska-Ciesielska, Jacek Drobnik, Joanna Zarzyńska, Kamila Domińska, John A. Russell, Tomasz Ochędalski
DOI: 10.5603/FHC.2011.0070
·
Folia Histochem Cytobiol 2011;49(3):497-503.
Vol 49, No 3 (2011)
ORIGINAL PAPERS
Submitted: 2012-01-05
Published online: 2011-10-28
Abstract
Angiotensin II (AngII) is the biologically active peptide of the renin-angiotensin system (RAS). Tissue-
based, local RAS has been identified in the prostate, testis, epididymis and coagulating glands. Experimental
and clinical studies have consistently shown that myocardial infarction (MI) is associated with activation of
the systemic RAS with increased concentration of angiotensin peptides in the blood and changes in expression
of angiotensin receptors (AT). Changes in angiotensin receptors in the renal and cardiovascular system after MI
are well recognized, but the effects of MI influence on changes in other tissue like the prostate gland are unknown.
In the present study, we investigated the effect of myocardial infarction on angiotensin receptor protein
and mRNA expression in the rat prostate gland. MI model was established in Wistar rats by ligating the left
coronary artery (modified Selye method). The levels of AT1a-b and AT2 receptor mRNAs and proteins were
measured in the rat prostate. Our study demonstrates tissue-specific changes in AT1a-b and AT2 receptor expression
after myocardial infarction. The results show that MI has a strong influence on the expression of angiotensin
receptor type AT1 in the prostate at the protein and mRNA level. (Folia Histochemica et Cytobiologica
2011, Vol. 49, No. 3, 497–503)
Abstract
Angiotensin II (AngII) is the biologically active peptide of the renin-angiotensin system (RAS). Tissue-
based, local RAS has been identified in the prostate, testis, epididymis and coagulating glands. Experimental
and clinical studies have consistently shown that myocardial infarction (MI) is associated with activation of
the systemic RAS with increased concentration of angiotensin peptides in the blood and changes in expression
of angiotensin receptors (AT). Changes in angiotensin receptors in the renal and cardiovascular system after MI
are well recognized, but the effects of MI influence on changes in other tissue like the prostate gland are unknown.
In the present study, we investigated the effect of myocardial infarction on angiotensin receptor protein
and mRNA expression in the rat prostate gland. MI model was established in Wistar rats by ligating the left
coronary artery (modified Selye method). The levels of AT1a-b and AT2 receptor mRNAs and proteins were
measured in the rat prostate. Our study demonstrates tissue-specific changes in AT1a-b and AT2 receptor expression
after myocardial infarction. The results show that MI has a strong influence on the expression of angiotensin
receptor type AT1 in the prostate at the protein and mRNA level. (Folia Histochemica et Cytobiologica
2011, Vol. 49, No. 3, 497–503)
Keywords
angiotensin receptor; myocardial infarction; prostate; rat
Title
Influence of myocardial infarction on changes in the expression of angiotensin type 1 receptor in the rat prostate
Journal
Folia Histochemica et Cytobiologica
Issue
Vol 49, No 3 (2011)
Article type
Original paper
Pages
497-503
Published online
2011-10-28
Page views
2130
Article views/downloads
2192
DOI
10.5603/FHC.2011.0070
Bibliographic record
Folia Histochem Cytobiol 2011;49(3):497-503.
Keywords
angiotensin receptor
myocardial infarction
prostate
rat
Authors
Agnieszka W. Piastowska-Ciesielska
Jacek Drobnik
Joanna Zarzyńska
Kamila Domińska
John A. Russell
Tomasz Ochędalski