Vol 49, No 3 (2011)
Original paper
Submitted: 2012-01-05
Published online: 2011-10-28
Comparative analysis of biological profiles of benign prostate hyperplasia and prostate cancer as potential diagnostic, prognostic and predictive indicators
Roman Makarewicz, Agnieszka Zyromska, Hanna Andrusewicz
DOI: 10.5603/FHC.2011.0064
·
Folia Histochem Cytobiol 2011;49(3):452-457.
Vol 49, No 3 (2011)
ORIGINAL PAPERS
Submitted: 2012-01-05
Published online: 2011-10-28
Abstract
The prognosis in prostate cancer depends on several clinical-morphological factors, such as Gleason
score, pTNM and preoperative PSA level. Reliable biological markers are being sought to supplement clinicalmorphological
data in order to better predict prognosis and to select an individualized therapeutic option. The
aim of this study was a comparative analysis of the expression of biological markers, such as Hif-1α, bcl-2, p53,
Ki-67, cyclin D1 and CD44 in BPH and prostate cancer, as well as examining their association with standard
prognostic factors in prostate cancer. The immunohistochemical analysis was made on 82 formalin-fixed, paraffin-
embedded tissue blocks: 43 prostate cancer specimens derived from patients who had undergone radical
resection, and 39 prostate bioptates derived from patients with BPH. A positive correlation was demonstrated
between Gleason score and the expression of both Hif-1α (R = 0.32, p < 0.05) and Ki-67 (R = 0.30, p < 0.05).
Additionally, a negative correlation was demonstrated between tumor stage (pTNM) and bcl-2 expression
(R = –0.35, p < 0.05). Hif-1α as a hypoxia marker and Ki-67 as a proliferation marker, both correlated with
Gleason score, may constitute important additional prognostic indicators in prostate cancer patients.
(Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 3, pp. 452–457)
Abstract
The prognosis in prostate cancer depends on several clinical-morphological factors, such as Gleason
score, pTNM and preoperative PSA level. Reliable biological markers are being sought to supplement clinicalmorphological
data in order to better predict prognosis and to select an individualized therapeutic option. The
aim of this study was a comparative analysis of the expression of biological markers, such as Hif-1α, bcl-2, p53,
Ki-67, cyclin D1 and CD44 in BPH and prostate cancer, as well as examining their association with standard
prognostic factors in prostate cancer. The immunohistochemical analysis was made on 82 formalin-fixed, paraffin-
embedded tissue blocks: 43 prostate cancer specimens derived from patients who had undergone radical
resection, and 39 prostate bioptates derived from patients with BPH. A positive correlation was demonstrated
between Gleason score and the expression of both Hif-1α (R = 0.32, p < 0.05) and Ki-67 (R = 0.30, p < 0.05).
Additionally, a negative correlation was demonstrated between tumor stage (pTNM) and bcl-2 expression
(R = –0.35, p < 0.05). Hif-1α as a hypoxia marker and Ki-67 as a proliferation marker, both correlated with
Gleason score, may constitute important additional prognostic indicators in prostate cancer patients.
(Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 3, pp. 452–457)
Keywords
prostate cancer; benign prostate hyperplasia; biomarkers
Title
Comparative analysis of biological profiles of benign prostate hyperplasia and prostate cancer as potential diagnostic, prognostic and predictive indicators
Journal
Folia Histochemica et Cytobiologica
Issue
Vol 49, No 3 (2011)
Article type
Original paper
Pages
452-457
Published online
2011-10-28
Page views
1359
Article views/downloads
1643
DOI
10.5603/FHC.2011.0064
Bibliographic record
Folia Histochem Cytobiol 2011;49(3):452-457.
Keywords
prostate cancer
benign prostate hyperplasia
biomarkers
Authors
Roman Makarewicz
Agnieszka Zyromska
Hanna Andrusewicz
About this article