Vol 49, No 3 (2011)
Original paper
Published online: 2011-10-28
The expression profile of Fc Receptor-like Y in B lymphocytes with hepatitis B virus induced diseases
DOI: 10.5603/FHC.2011.0057
Folia Histochem Cytobiol 2011;49(3):405-409.
Abstract
The Fc Receptor-like Y (FcRY) molecule is preferentially expressed by B lymphocytes and has recently
been considered as a potential therapeutic target for B cell malignancies. In this study, we investigated the
correlation between FcRY expression profile, B lymphocytes population and different HBV infection disease
status. The FcRY expression level on B lymphocytes and the number of B lymphocytes population from peripheral
blood in 27 healthy controls (HC) and 65 patients with HBV-induced diseases, including chronic hepatitis B
(CHB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC), were analyzed using quantitative real-time
PCR and flow cytometry. The results showed the level of FcRY expression and frequency of germinal center
(GC) B lymphocytes from peripheral blood were significantly correlated with the HBV-related disease status,
which was highest in HCC and LC patients, lowest in healthy donors, and in the middle in patients with CHB.
Our study indicates that there is a significant correlation between FcRY expression profile, B lymphocytes population
and HBV-induced diseases. However, the roles of FcRY and B lymphocytes in HBV-induced diseases
are unclear and need further investigation. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 3, pp. 405–409)
Keywords: Fc Receptor-like YB lymphocytesgerminal center B lymphocyteshepatitis B virusgene expression
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