Correlation between Fas and FasL proteins expression in normal gastric mucosa and gastric cancer

Mariusz Gryko; Katarzyna Guzińska-Ustymowicz; Anna Pryczynicz; Dariusz Cepowicz; Adam Kukliński; Jolanta Czyżewska; Andrzej Kemona; Bogusław Kędra

doi:10.5603/FHC.2011.0020

Vol 49, No 1 (2011)

Original paper

Submitted: 2011-12-19

Published online: 2011-04-19

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Correlation between Fas and FasL proteins expression in normal gastric mucosa and gastric cancer

Mariusz Gryko, Katarzyna Guzińska-Ustymowicz, Anna Pryczynicz, Dariusz Cepowicz, Adam Kukliński, Jolanta Czyżewska, Andrzej Kemona, Bogusław Kędra

DOI: 10.5603/FHC.2011.0020

Folia Histochem Cytobiol 2011;49(1):142-147.

Vol 49, No 1 (2011)

ORIGINAL PAPERS

Submitted: 2011-12-19

Published online: 2011-04-19

Abstract

The study’s objective was to assess the expressions of Fas and FasL proteins in gastric cancer in correlation with chosen clinicohistological parameters. Fas and FasL expression was analyzed in 68 patients with gastric cancer, using the immunohistochemical method. The expression of Fas was found to be lower in gastric cancer cells than in healthy mucosa, both in the lining epithelium and in glandular tubes (28% vs. 48% and 44%; p < 0.001). The expression of FasL was also markedly lower in cancer cells than in glandular tubes, yet higher than in the lining epithelium (51% vs. 73% and 14%; p < 0.01). Positive expressions of FasL and Fas were lower in less advanced gastric cancer cells (T1, T2), than in more advanced tumors (T3, T4), but only in the case of FasL was this difference statistically significant (p < 0.05). Our findings seem to confirm the theory of the impact of apoptotic disorders at the level of Fas receptor and FasL protein in the process of gastric cancer formation and growth, which is manifested in the varied expressions of these proteins in gastric cancer and in the normal lining and glandular epithelium of the stomach. However, the lack of significant differences in the expressions of Fas and FasL in correlation to other clinicohistological parameters indicates the existence of mechanisms that have a greater impact on the process of differentiation of gastric cancers. This in our opinion eliminates these proteins as prognostic factors. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 1, pp. 142–147)

Abstract

The study’s objective was to assess the expressions of Fas and FasL proteins in gastric cancer in correlation with chosen clinicohistological parameters. Fas and FasL expression was analyzed in 68 patients with gastric cancer, using the immunohistochemical method. The expression of Fas was found to be lower in gastric cancer cells than in healthy mucosa, both in the lining epithelium and in glandular tubes (28% vs. 48% and 44%; p < 0.001). The expression of FasL was also markedly lower in cancer cells than in glandular tubes, yet higher than in the lining epithelium (51% vs. 73% and 14%; p < 0.01). Positive expressions of FasL and Fas were lower in less advanced gastric cancer cells (T1, T2), than in more advanced tumors (T3, T4), but only in the case of FasL was this difference statistically significant (p < 0.05). Our findings seem to confirm the theory of the impact of apoptotic disorders at the level of Fas receptor and FasL protein in the process of gastric cancer formation and growth, which is manifested in the varied expressions of these proteins in gastric cancer and in the normal lining and glandular epithelium of the stomach. However, the lack of significant differences in the expressions of Fas and FasL in correlation to other clinicohistological parameters indicates the existence of mechanisms that have a greater impact on the process of differentiation of gastric cancers. This in our opinion eliminates these proteins as prognostic factors. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 1, pp. 142–147)

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Keywords

gastric cancer; Fas; FasL; Helicobacter pylori

About this article

Title

Correlation between Fas and FasL proteins expression in normal gastric mucosa and gastric cancer

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 49, No 1 (2011)

Article type

Original paper

Pages

142-147

Published online

2011-04-19

Page views

1731

Article views/downloads

1825

DOI

10.5603/FHC.2011.0020

Bibliographic record

Folia Histochem Cytobiol 2011;49(1):142-147.

Keywords

gastric cancer
Fas
FasL
Helicobacter pylori

Authors

Mariusz Gryko
Katarzyna Guzińska-Ustymowicz
Anna Pryczynicz
Dariusz Cepowicz
Adam Kukliński
Jolanta Czyżewska
Andrzej Kemona
Bogusław Kędra