Vol 49, No 3 (2011)
Original paper
Published online: 2011-10-28
Comparative analysis of biological profiles of benign prostate hyperplasia and prostate cancer as potential diagnostic, prognostic and predictive indicators
DOI: 10.5603/FHC.2011.0064
Folia Histochem Cytobiol 2011;49(3):452-457.
Abstract
The prognosis in prostate cancer depends on several clinical-morphological factors, such as Gleason
score, pTNM and preoperative PSA level. Reliable biological markers are being sought to supplement clinicalmorphological
data in order to better predict prognosis and to select an individualized therapeutic option. The
aim of this study was a comparative analysis of the expression of biological markers, such as Hif-1α, bcl-2, p53,
Ki-67, cyclin D1 and CD44 in BPH and prostate cancer, as well as examining their association with standard
prognostic factors in prostate cancer. The immunohistochemical analysis was made on 82 formalin-fixed, paraffin-
embedded tissue blocks: 43 prostate cancer specimens derived from patients who had undergone radical
resection, and 39 prostate bioptates derived from patients with BPH. A positive correlation was demonstrated
between Gleason score and the expression of both Hif-1α (R = 0.32, p < 0.05) and Ki-67 (R = 0.30, p < 0.05).
Additionally, a negative correlation was demonstrated between tumor stage (pTNM) and bcl-2 expression
(R = –0.35, p < 0.05). Hif-1α as a hypoxia marker and Ki-67 as a proliferation marker, both correlated with
Gleason score, may constitute important additional prognostic indicators in prostate cancer patients.
(Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 3, pp. 452–457)
Keywords: prostate cancerbenign prostate hyperplasiabiomarkers
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