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Vol 49, No 3 (2011)
Original paper
Submitted: 2012-01-05
Published online: 2011-10-28
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The expression profile of Fc Receptor-like Y in B lymphocytes with hepatitis B virus induced diseases

Ke Wang, Run-Lin Yang, Hao Pei, Hang-Yuan Wu, Jue Zhang, Biao Huang
DOI: 10.5603/FHC.2011.0057
·
Folia Histochem Cytobiol 2011;49(3):405-409.

open access

Vol 49, No 3 (2011)
ORIGINAL PAPERS
Submitted: 2012-01-05
Published online: 2011-10-28

Abstract

The Fc Receptor-like Y (FcRY) molecule is preferentially expressed by B lymphocytes and has recently been considered as a potential therapeutic target for B cell malignancies. In this study, we investigated the correlation between FcRY expression profile, B lymphocytes population and different HBV infection disease status. The FcRY expression level on B lymphocytes and the number of B lymphocytes population from peripheral blood in 27 healthy controls (HC) and 65 patients with HBV-induced diseases, including chronic hepatitis B (CHB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC), were analyzed using quantitative real-time PCR and flow cytometry. The results showed the level of FcRY expression and frequency of germinal center (GC) B lymphocytes from peripheral blood were significantly correlated with the HBV-related disease status, which was highest in HCC and LC patients, lowest in healthy donors, and in the middle in patients with CHB. Our study indicates that there is a significant correlation between FcRY expression profile, B lymphocytes population and HBV-induced diseases. However, the roles of FcRY and B lymphocytes in HBV-induced diseases are unclear and need further investigation. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 3, pp. 405–409)

Abstract

The Fc Receptor-like Y (FcRY) molecule is preferentially expressed by B lymphocytes and has recently been considered as a potential therapeutic target for B cell malignancies. In this study, we investigated the correlation between FcRY expression profile, B lymphocytes population and different HBV infection disease status. The FcRY expression level on B lymphocytes and the number of B lymphocytes population from peripheral blood in 27 healthy controls (HC) and 65 patients with HBV-induced diseases, including chronic hepatitis B (CHB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC), were analyzed using quantitative real-time PCR and flow cytometry. The results showed the level of FcRY expression and frequency of germinal center (GC) B lymphocytes from peripheral blood were significantly correlated with the HBV-related disease status, which was highest in HCC and LC patients, lowest in healthy donors, and in the middle in patients with CHB. Our study indicates that there is a significant correlation between FcRY expression profile, B lymphocytes population and HBV-induced diseases. However, the roles of FcRY and B lymphocytes in HBV-induced diseases are unclear and need further investigation. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 3, pp. 405–409)

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Keywords

Fc Receptor-like Y; B lymphocytes; germinal center B lymphocytes; hepatitis B virus; gene expression

About this article
Title

The expression profile of Fc Receptor-like Y in B lymphocytes with hepatitis B virus induced diseases

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 49, No 3 (2011)

Article type

Original paper

Pages

405-409

Published online

2011-10-28

Page views

1484

Article views/downloads

1709

DOI

10.5603/FHC.2011.0057

Bibliographic record

Folia Histochem Cytobiol 2011;49(3):405-409.

Keywords

Fc Receptor-like Y
B lymphocytes
germinal center B lymphocytes
hepatitis B virus
gene expression

Authors

Ke Wang
Run-Lin Yang
Hao Pei
Hang-Yuan Wu
Jue Zhang
Biao Huang

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