Chromogranin A in pituitary adenomas: immunohistochemical detection and plasma concentrations.

Marek Pawlikowski; Anna Gruszka; Maciej Radek; Jolanta Kunert-Radek

Vol 42, No 4 (2004)

Original paper

Submitted: 2011-12-19

Published online: 2005-02-12

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Chromogranin A in pituitary adenomas: immunohistochemical detection and plasma concentrations.

Marek Pawlikowski, Anna Gruszka, Maciej Radek, Jolanta Kunert-Radek

Folia Histochem Cytobiol 2004;42(4):245-247.

Vol 42, No 4 (2004)

ORIGINAL PAPERS

Submitted: 2011-12-19

Published online: 2005-02-12

Abstract

Forty one pituitary adenomas excised surgically were immunostained to reveal pituitary hormones and chromogranin A (CgA). In 23 patients, plasma CgA concentration was determined before surgery by ELISA method. The CgA immunopositivity was found in 70.7% of investigated tumors. It was observed in all tumors of gonadotropinoma type and in the majority of null cell adenomas. Elevated (>18 U/L) plasma CgA concentration was observed in approx. a half of the examined patients, being more frequent in gonadotropinomas and null cell adenomas. It may have some, although limited, diagnostic value in these types of pituitary tumors.