open access

Vol 42, No 4 (2004)
Original paper
Submitted: 2011-12-19
Published online: 2005-02-12
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Chromogranin A in pituitary adenomas: immunohistochemical detection and plasma concentrations.

Marek Pawlikowski, Anna Gruszka, Maciej Radek, Jolanta Kunert-Radek
Folia Histochem Cytobiol 2004;42(4):245-247.

open access

Vol 42, No 4 (2004)
ORIGINAL PAPERS
Submitted: 2011-12-19
Published online: 2005-02-12

Abstract

Forty one pituitary adenomas excised surgically were immunostained to reveal pituitary hormones and chromogranin A (CgA). In 23 patients, plasma CgA concentration was determined before surgery by ELISA method. The CgA immunopositivity was found in 70.7% of investigated tumors. It was observed in all tumors of gonadotropinoma type and in the majority of null cell adenomas. Elevated (>18 U/L) plasma CgA concentration was observed in approx. a half of the examined patients, being more frequent in gonadotropinomas and null cell adenomas. It may have some, although limited, diagnostic value in these types of pituitary tumors.

Abstract

Forty one pituitary adenomas excised surgically were immunostained to reveal pituitary hormones and chromogranin A (CgA). In 23 patients, plasma CgA concentration was determined before surgery by ELISA method. The CgA immunopositivity was found in 70.7% of investigated tumors. It was observed in all tumors of gonadotropinoma type and in the majority of null cell adenomas. Elevated (>18 U/L) plasma CgA concentration was observed in approx. a half of the examined patients, being more frequent in gonadotropinomas and null cell adenomas. It may have some, although limited, diagnostic value in these types of pituitary tumors.
Get Citation
About this article
Title

Chromogranin A in pituitary adenomas: immunohistochemical detection and plasma concentrations.

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 42, No 4 (2004)

Article type

Original paper

Pages

245-247

Published online

2005-02-12

Bibliographic record

Folia Histochem Cytobiol 2004;42(4):245-247.

Authors

Marek Pawlikowski
Anna Gruszka
Maciej Radek
Jolanta Kunert-Radek

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