Vol 43, No 1 (2005)
Original paper
Published online: 2011-08-19
Prognostic evaluation of CD44 expression in correlation with bcl-2 and p53 in colorectal cancer
Folia Histochem Cytobiol 2005;43(1):31-36.
Abstract
To investigate the expression of CD44 in colorectal cancer and examine its association with clinicopathological
features, bcl-2, p53 and long-term outcome, paraffin-embedded tumour specimens from 61 patients with Dukes stage B
(AJCC/UICC stage I) and 39 patients with Dukes stage C (AJCC/UICC stage III) colorectal adenocarcinoma were assessed
by immunohistochemistry. The expression of CD44, bcl-2 and p53 were correlated with 5-year follow-up. Low CD44
expression was present in 30%, moderate in 30% and extensive in 40% of cases. It was not related to patient sex and age but
was related to tumour differentiation, stage and tumour site. No association was demonstrated between CD44 and bcl-2.
However, there was significant evidence of an association between CD44 and p53 in 66 cases in which p53 was previously
assessed. There was a trend towards increased survival in patients whose tumours expressed lower levels of CD44 protein.
When entered into multivariate analysis model, which also included bcl-2 and p53, CD44 staining emerged as an indicator of
poor prognosis in colorectal cancer patients.
Keywords: CD44Colorectal cancerBcl-2P53Prognosis
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