open access

Vol 43, No 1 (2005)
Original paper
Submitted: 2011-12-19
Published online: 2011-08-19
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Prognostic evaluation of CD44 expression in correlation with bcl-2 and p53 in colorectal cancer

H.N. Zavrides, A. Zizi-Sermpetzoglou, D. Panousopoulos, G. Athanasas, I. Elemenoglou, G. Peros
Folia Histochem Cytobiol 2005;43(1):31-36.

open access

Vol 43, No 1 (2005)
ORIGINAL PAPERS
Submitted: 2011-12-19
Published online: 2011-08-19

Abstract

To investigate the expression of CD44 in colorectal cancer and examine its association with clinicopathological features, bcl-2, p53 and long-term outcome, paraffin-embedded tumour specimens from 61 patients with Dukes stage B (AJCC/UICC stage I) and 39 patients with Dukes stage C (AJCC/UICC stage III) colorectal adenocarcinoma were assessed by immunohistochemistry. The expression of CD44, bcl-2 and p53 were correlated with 5-year follow-up. Low CD44 expression was present in 30%, moderate in 30% and extensive in 40% of cases. It was not related to patient sex and age but was related to tumour differentiation, stage and tumour site. No association was demonstrated between CD44 and bcl-2. However, there was significant evidence of an association between CD44 and p53 in 66 cases in which p53 was previously assessed. There was a trend towards increased survival in patients whose tumours expressed lower levels of CD44 protein. When entered into multivariate analysis model, which also included bcl-2 and p53, CD44 staining emerged as an indicator of poor prognosis in colorectal cancer patients.

Abstract

To investigate the expression of CD44 in colorectal cancer and examine its association with clinicopathological features, bcl-2, p53 and long-term outcome, paraffin-embedded tumour specimens from 61 patients with Dukes stage B (AJCC/UICC stage I) and 39 patients with Dukes stage C (AJCC/UICC stage III) colorectal adenocarcinoma were assessed by immunohistochemistry. The expression of CD44, bcl-2 and p53 were correlated with 5-year follow-up. Low CD44 expression was present in 30%, moderate in 30% and extensive in 40% of cases. It was not related to patient sex and age but was related to tumour differentiation, stage and tumour site. No association was demonstrated between CD44 and bcl-2. However, there was significant evidence of an association between CD44 and p53 in 66 cases in which p53 was previously assessed. There was a trend towards increased survival in patients whose tumours expressed lower levels of CD44 protein. When entered into multivariate analysis model, which also included bcl-2 and p53, CD44 staining emerged as an indicator of poor prognosis in colorectal cancer patients.
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Keywords

CD44; Colorectal cancer; Bcl-2; P53; Prognosis

About this article
Title

Prognostic evaluation of CD44 expression in correlation with bcl-2 and p53 in colorectal cancer

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 43, No 1 (2005)

Article type

Original paper

Pages

31-36

Published online

2011-08-19

Bibliographic record

Folia Histochem Cytobiol 2005;43(1):31-36.

Keywords

CD44
Colorectal cancer
Bcl-2
P53
Prognosis

Authors

H.N. Zavrides
A. Zizi-Sermpetzoglou
D. Panousopoulos
G. Athanasas
I. Elemenoglou
G. Peros

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