open access

Vol 43, No 1 (2005)
Review paper
Submitted: 2011-12-19
Published online: 2011-08-19
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Rafts - the current picture

Michał Grzybek, Agnieszka Kozubek, Patrycja Dubielecka, Aleksander F. Sikorski
Folia Histochem Cytobiol 2005;43(1):3-10.

open access

Vol 43, No 1 (2005)
REVIEW
Submitted: 2011-12-19
Published online: 2011-08-19

Abstract

Although evidences that cell membrane contains microdomains are accumulating, the exact properties, diversity and levels of organization of small lipid patches built mainly of cholesterol and sphingomyelin, termed rafts, remain to be elucidated. Our understanding of the cell membrane is increasing with each new raft feature discovered. Nowadays rafts are suggested to act as sites of cell signaling events, to be a part of protein sorting machinery but also they are used by several pathogens as gates into the cells. It is still unclear how rafts are connected to the membrane skeleton and cytoskeleton and with how many different types of rafts are we actually dealing with. This review summarizes some of the most recent discoveries trying to make a view of the complex raft properties.

Abstract

Although evidences that cell membrane contains microdomains are accumulating, the exact properties, diversity and levels of organization of small lipid patches built mainly of cholesterol and sphingomyelin, termed rafts, remain to be elucidated. Our understanding of the cell membrane is increasing with each new raft feature discovered. Nowadays rafts are suggested to act as sites of cell signaling events, to be a part of protein sorting machinery but also they are used by several pathogens as gates into the cells. It is still unclear how rafts are connected to the membrane skeleton and cytoskeleton and with how many different types of rafts are we actually dealing with. This review summarizes some of the most recent discoveries trying to make a view of the complex raft properties.
Get Citation

Keywords

Rafts; Detergent-resistant membranes; Membrane skeleton; Immunological synapse

About this article
Title

Rafts - the current picture

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 43, No 1 (2005)

Article type

Review paper

Pages

3-10

Published online

2011-08-19

Bibliographic record

Folia Histochem Cytobiol 2005;43(1):3-10.

Keywords

Rafts
Detergent-resistant membranes
Membrane skeleton
Immunological synapse

Authors

Michał Grzybek
Agnieszka Kozubek
Patrycja Dubielecka
Aleksander F. Sikorski

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