Vol 43, No 3 (2005)
Original paper
Published online: 2011-08-22
Lower expression of mRNA for interferon-gamma in T helper cells of children with newly diagnosed lymphomas
Folia Histochem Cytobiol 2005;43(3):169-171.
Abstract
The complex interactions between cancer and host cells are far from being fully elucidated. Assessment of
Th1/Th2/Th3/Tr1 balance is an interesting approach to explain immunological disturbances in lymphomas. The aim of our
study was to assess mRNA for pro- and anti-inflammatory cytokines in T-cells in 20 children with Hodgkin- and non-Hodgkin
lymphomas. CD4+ and CD8+ cells were isolated from whole peripheral blood and four different cytokine mRNA levels (IFN-γ,
IL-10, IL-4, TGF-β) were determined by real-time PCR technique. Comparing to the control group, we found lower expression
of mRNA for IFN-gamma in CD4+ cells at the time of lymphoma diagnosis. It may be one of the pathogenetic mechanisms of
impaired immunity in these patients.
Keywords: LymphomaChildrenT-cellsInterferon-gammaImmunosuppression
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