Basic fibroblast growth factor and its receptors in human embryonic stem cells.

Petr Dvorak, Ales Hampl
Folia Histochem Cytobiol 2005;43(4):203-208.

open access

Vol 43, No 4 (2005)
Original Papers
Published online: 2005-12-31
Submitted: 2011-12-19


Human embryonic stem cells (hESCs) are pluripotent stem cells with long-lasting capacity to self-renew and differentiate into various cell types of endodermal, ectodermal or mesodermal origin. Unlike mouse ESCs (mESCs), which can be maintained in an undifferentiated state simply by adding leukemia inhibitory factor (LIF) into the culture medium, hESCs are notorious for the sustained willingness to differentiate and not yet clearly defined signaling pathways that are crucial for their "stemness". Presently, our knowledge involves only limited number of growth factor signaling pathways that appear to be biologically relevant for stem cell functions in vitro. These include BMP, TGFbeta, Wnt, and FGF signaling pathway. The purpose of this review is to summarize recent data on the expression of FGFs and their receptors in hESCs, and critically evaluate the potential effects of FGF signals for their undifferentiated growth and/or differentiation in context with our current understanding of FGF/FGFR biology.
About this article

Basic fibroblast growth factor and its receptors in human embryonic stem cells.


Folia Histochemica et Cytobiologica


Vol 43, No 4 (2005)



Published online


Bibliographic record

Folia Histochem Cytobiol 2005;43(4):203-208.


Petr Dvorak
Ales Hampl

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