open access

Vol 43, No 4 (2005)
Original paper
Submitted: 2011-12-19
Published online: 2005-12-31
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Proliferative senescence in hematopoietic stem cells during ex-vivo expansion.

Wanda Piacibello, Loretta Gammaitoni, Ymera Pignochino
Folia Histochem Cytobiol 2005;43(4):197-202.

open access

Vol 43, No 4 (2005)
ORIGINAL PAPERS
Submitted: 2011-12-19
Published online: 2005-12-31

Abstract

The good outcome of hematopoietic stem cell (HSC) transplantation is hampered by low doses of CD34+ cell infusion. Transplanted HSCs undergo a replicative stress that causes accelerated senescence due to rapid telomere shortening. The expansion of human cord blood HSCs is instrumental in obtaining a large number of "good quality" cells, in terms of telomere length and telomerase activity compared to adult HSCs.

Abstract

The good outcome of hematopoietic stem cell (HSC) transplantation is hampered by low doses of CD34+ cell infusion. Transplanted HSCs undergo a replicative stress that causes accelerated senescence due to rapid telomere shortening. The expansion of human cord blood HSCs is instrumental in obtaining a large number of "good quality" cells, in terms of telomere length and telomerase activity compared to adult HSCs.
Get Citation
About this article
Title

Proliferative senescence in hematopoietic stem cells during ex-vivo expansion.

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 43, No 4 (2005)

Article type

Original paper

Pages

197-202

Published online

2005-12-31

Bibliographic record

Folia Histochem Cytobiol 2005;43(4):197-202.

Authors

Wanda Piacibello
Loretta Gammaitoni
Ymera Pignochino

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