Vol 43, No 4 (2005)
Original paper
Published online: 2005-12-31

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Proliferative senescence in hematopoietic stem cells during ex-vivo expansion.

Wanda Piacibello, Loretta Gammaitoni, Ymera Pignochino
Folia Histochem Cytobiol 2005;43(4):197-202.


The good outcome of hematopoietic stem cell (HSC) transplantation is hampered by low doses of CD34+ cell infusion. Transplanted HSCs undergo a replicative stress that causes accelerated senescence due to rapid telomere shortening. The expansion of human cord blood HSCs is instrumental in obtaining a large number of "good quality" cells, in terms of telomere length and telomerase activity compared to adult HSCs.

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