Vol 43, No 4 (2005)
Review paper
Submitted: 2011-12-19
Published online: 2005-12-31
Cancer stem cells - normal stem cells "Jedi" that went over to the "dark side"
Mariusz Z. Ratajczak
Folia Histochem Cytobiol 2005;43(4):115-121.
Vol 43, No 4 (2005)
REVIEW
Submitted: 2011-12-19
Published online: 2005-12-31
Abstract
Evidence has accumulated that cancer develops from a population of quiescent tissue committed/pluripotent stem
cells (TCSC/PSC) or cells developmentally closely related to them that are distributed in various organs. To support this notion,
stem cells (SC) are long lived cells and thus may become the subject of accumulating mutations that are crucial for
initiation/progression of cancer. More important, they may maintain these mutations and pass them to the daughter stem cells.
Therefore, mutations that occur in normal SC, accumulate during the life of an organism at the clonal level in the stem cell
compartment committed to a given tissue/organ. As a consequence, this may lead to the malignant transformation of SC and
tumor initiation. Furthermore, many biological features of normal and cancer SC such as the physiological trafficking of normal
and metastasis of cancer stem cells involve similar molecular mechanisms, and we discuss these similarities here. Therefore,
looking both at the origin and behavioral aspects we can envision cancer SC being normal SC "Jedi" that went over to the "dark
side".
Abstract
Evidence has accumulated that cancer develops from a population of quiescent tissue committed/pluripotent stem
cells (TCSC/PSC) or cells developmentally closely related to them that are distributed in various organs. To support this notion,
stem cells (SC) are long lived cells and thus may become the subject of accumulating mutations that are crucial for
initiation/progression of cancer. More important, they may maintain these mutations and pass them to the daughter stem cells.
Therefore, mutations that occur in normal SC, accumulate during the life of an organism at the clonal level in the stem cell
compartment committed to a given tissue/organ. As a consequence, this may lead to the malignant transformation of SC and
tumor initiation. Furthermore, many biological features of normal and cancer SC such as the physiological trafficking of normal
and metastasis of cancer stem cells involve similar molecular mechanisms, and we discuss these similarities here. Therefore,
looking both at the origin and behavioral aspects we can envision cancer SC being normal SC "Jedi" that went over to the "dark
side".
Keywords
Cancer stem cells; CXCR4; SDF-1; HGF/SF; LIF; Metastasis
Title
Cancer stem cells - normal stem cells "Jedi" that went over to the "dark side"
Journal
Folia Histochemica et Cytobiologica
Issue
Vol 43, No 4 (2005)
Article type
Review paper
Pages
115-121
Published online
2005-12-31
Page views
1200
Article views/downloads
1146
Bibliographic record
Folia Histochem Cytobiol 2005;43(4):115-121.
Keywords
Cancer stem cells
CXCR4
SDF-1
HGF/SF
LIF
Metastasis
Authors
Mariusz Z. Ratajczak