open access
Vol 45, No 3 (2007)
Original paper
Submitted: 2011-12-19
Published online: 2007-10-24
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Regulatory role of cathepsin D in apoptosis.
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Folia Histochem Cytobiol 2007;45(3):159-163.
open access
Vol 45, No 3 (2007)
ORIGINAL PAPERS
Submitted: 2011-12-19
Published online: 2007-10-24
Abstract
Cathepsin D (CTSD, EC 3.4.23.5) is well known aspartyl protease. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. Cathepsin D can either induce apoptosis in presence of cytotoxic factors, but in certain studies an inhibitory role in apoptosis was also reviewed. Detailed review of involvement of cathepsin D in cell apoptosis is a purpose of this paper.
Abstract
Cathepsin D (CTSD, EC 3.4.23.5) is well known aspartyl protease. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. Cathepsin D can either induce apoptosis in presence of cytotoxic factors, but in certain studies an inhibitory role in apoptosis was also reviewed. Detailed review of involvement of cathepsin D in cell apoptosis is a purpose of this paper.
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About this articleTitle
Regulatory role of cathepsin D in apoptosis.
Journal
Folia Histochemica et Cytobiologica
Issue
Article type
Original paper
Pages
159-163
Published online
2007-10-24
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2168
Article views/downloads
2167
Bibliographic record
Folia Histochem Cytobiol 2007;45(3):159-163.
Authors
Alina Minarowska
Lukasz Minarowski
Alicja Karwowska
Marek Gacko
