open access

Vol 45, Supp. I (2007)
ORIGINAL PAPERS
Published online: 2008-04-15
Submitted: 2011-12-19
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Pronuclear scoring as a predictor of embryo quality in in vitro fertilization program.

Magdalena Depa-Martynow, Piotr Jedrzejczak, Leszek Pawelczyk

open access

Vol 45, Supp. I (2007)
ORIGINAL PAPERS
Published online: 2008-04-15
Submitted: 2011-12-19

Abstract

Many strategies have been proposed for the selection of viable embryos for transfer in human assisted reproduction. These have included morphological scoring criteria for 20, 28, 44 and 68 h after insemination. The embryo selection is based on morphology, degree of fragmentation and development to the 8-cell. All have shown some correlation with implantation. However, the overall success of these methods is still limited, with over 50% of all transferred embryos failing to implant. Pronuclear zygote morphology has gained much attention recently due to its positive value in predicting implantation and pregnancy. This prospective study involved 178 conventional IVF patients only. The key aspects of pronuclear scoring and namely the presence of a cytoplasmic halo were related to day 3 of development and morphology in a retrospective study. The Z-score and the presence/absence of a halo had significant effect on the rate of development on day 3 embryo. Low Z-score result in slow development and poor morphology. The absence of a halo also resulted in slow and poor development, low morphology, increased fragmentation.

Abstract

Many strategies have been proposed for the selection of viable embryos for transfer in human assisted reproduction. These have included morphological scoring criteria for 20, 28, 44 and 68 h after insemination. The embryo selection is based on morphology, degree of fragmentation and development to the 8-cell. All have shown some correlation with implantation. However, the overall success of these methods is still limited, with over 50% of all transferred embryos failing to implant. Pronuclear zygote morphology has gained much attention recently due to its positive value in predicting implantation and pregnancy. This prospective study involved 178 conventional IVF patients only. The key aspects of pronuclear scoring and namely the presence of a cytoplasmic halo were related to day 3 of development and morphology in a retrospective study. The Z-score and the presence/absence of a halo had significant effect on the rate of development on day 3 embryo. Low Z-score result in slow development and poor morphology. The absence of a halo also resulted in slow and poor development, low morphology, increased fragmentation.
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About this article
Title

Pronuclear scoring as a predictor of embryo quality in in vitro fertilization program.

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 45, Supp. I (2007)

Pages

85-89

Published online

2008-04-15

Authors

Magdalena Depa-Martynow
Piotr Jedrzejczak
Leszek Pawelczyk

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