Vol 46, No 2 (2008)
Original paper
Published online: 2008-06-04

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Dendritic cells based immunotherapy of patient with chondrosarcoma--case report.

Jacek Tabarkiewicz, Sebastian Radej, Iwona Hus, Magdalena Wasiak, Paulina Wdowiak, Krzysztof Giannopoulos, Beata Piechnik, Adam Kłos, Anna Dmoszyńska, Jacek Rolinski
DOI: 10.2478/v10042-008-0025-4
Folia Histochem Cytobiol 2008;46(2):165-170.

Abstract

We present a case report of patient with intracranial chondrosarcoma and attempt to use vaccination of dendritic cells as the salvage therapy. To our knowledge, this is the first case report of DCs vaccination in the head and neck chondrosarcoma. Immunotherapy with allogeneic DCs stimulated with tumor cell lysates in this case was demonstrated to be feasible, safe and well tolerated. Unfortunately we did not observe any clinical or immune response during vaccination. CD4+ and CD8+ regulatory cells could be responsible for ineffectiveness of immunotherapy.

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