Vol 46, No 4 (2008)
Original paper
Published online: 2009-01-15

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Molecular markers (c-erbB-2, p53) in breast cancer.

Anil Kumar Agrawal, Michał Jeleń, Jerzy Rudnicki, Zygmunt Grzebieniak, Piotr Zukrowski, Ewa Nienartowicz
DOI: 10.2478/v10042-008-0059-7
Folia Histochem Cytobiol 2008;46(4):449-455.

Abstract

The aim of our study was to evaluate the correlation between clinical characteristics, histopatologic features and c-erbB-2 as well as p53 expression in cancer tissues. Breast cancer tissue was obtained from 184 female subjects with primary breast cancer. According to hormonal status patients were divided into two groups - 64 belonged to the premenopausal group and 120 to postmenopausal group. Each patient underwent mammectomy and axillary lymphadenectomy. c-erbB-2 protooncogene was detected in 54% cases, and was correlated with infiltrating type of cancer growth, as well as larger tumor size. The presence of p53 antioncogene was observed only in 33% of cases, mainly in infiltrating duct carcinomas. The incidence of c-erbB-2 and p53 positive cases was higher among subjects, whose ultrasound and mammography revealed malignancy. There was no correlation found between of c-erbB-2 expression and axillary lymph nodes involvement It seems probable, that c-erbB-2 and p53 status of cancer tissue may prove to be useful in assessment of the level of biological aggressiveness in breast carcinomas and hence can be used as a prognostic factor.

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