open access
The influence of lovastatin on thrombomodulin gene expression in vascular endothelial cells--in vitro study.
open access
Abstract
Statins reduce lipids concentration in blood. The latest investigations show they also improved the function of vascular endothelial cells (ECs). Thrombomodulin (TM) is particularly important marker of ECs activity. We investigated the in vitro effect of lovastatin on the expression level of TM gene.
METHODS AND RESULTS
ECs were incubated for 24 h in culture medium including lovastatin in 3 concentrations: 0.1, 1.0, 10.0 mol/l. The mRNA level of TM increased in correlation with rising concentrations of lovastatin to 600 % vs. control group.
CONCLUSIONS
TM is essential antithrombotic factor in endothelial cells. Lovastatin significantly raises thrombomodulin gene expression. It is important characteristics of this medicine, which prevents cardiovascular events.
Abstract
Statins reduce lipids concentration in blood. The latest investigations show they also improved the function of vascular endothelial cells (ECs). Thrombomodulin (TM) is particularly important marker of ECs activity. We investigated the in vitro effect of lovastatin on the expression level of TM gene.
METHODS AND RESULTS
ECs were incubated for 24 h in culture medium including lovastatin in 3 concentrations: 0.1, 1.0, 10.0 mol/l. The mRNA level of TM increased in correlation with rising concentrations of lovastatin to 600 % vs. control group.
CONCLUSIONS
TM is essential antithrombotic factor in endothelial cells. Lovastatin significantly raises thrombomodulin gene expression. It is important characteristics of this medicine, which prevents cardiovascular events.
Title
The influence of lovastatin on thrombomodulin gene expression in vascular endothelial cells--in vitro study.
Journal
Folia Histochemica et Cytobiologica
Issue
Article type
Original paper
Pages
43-45
Published online
2009-05-08
Page views
1541
Article views/downloads
1554
DOI
10.2478/v10042-009-0012-4
Bibliographic record
Folia Histochem Cytobiol 2009;47(1):43-45.
Authors
Krzysztof Góralczyk
Krystyna Soszyńska
Olga Haus
Robert Bielis
Danuta Rość