open access

Vol 47, No 1 (2009)
ORIGINAL PAPERS
Published online: 2009-05-08
Submitted: 2011-12-19
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Mutations of the KRAS oncogene in endometrial hyperplasia and carcinoma.

Bozena Dobrzycka, Sławomir J Terlikowski, Andrzej Mazurek, Oksana Kowalczuk, Wiesława Niklińska, Lech Chyczewski, Marek Kulikowski
DOI: 10.2478/v10042-009-0014-2
·
Folia Histochem Cytobiol 2009;47(1):65-68.

open access

Vol 47, No 1 (2009)
ORIGINAL PAPERS
Published online: 2009-05-08
Submitted: 2011-12-19

Abstract

The aim of this study was to examine the prevalence and clinicopathological significance of KRAS point mutation in endometrial hyperplasia and carcinoma. We analysed KRAS in 11 cases of complex atypical hyperplasia and in 49 endometrial carcinomas using polymerase chain reaction associated with restriction fragment length polymorphism (PCR-RFPL). Point mutations at codon 12 of KRAS oncogene were identified in 7 of 49 (14,3%) tumor specimens and in 2 of 11 (18,2%) hyperplasias. No correlation was found between KRAS gene mutation and age at onset, histology, grade of differentiation and clinical stage. We conclude that KRAS mutation is a relatively common event in endometrial carcinogenesis, but with no prognostic value.

Abstract

The aim of this study was to examine the prevalence and clinicopathological significance of KRAS point mutation in endometrial hyperplasia and carcinoma. We analysed KRAS in 11 cases of complex atypical hyperplasia and in 49 endometrial carcinomas using polymerase chain reaction associated with restriction fragment length polymorphism (PCR-RFPL). Point mutations at codon 12 of KRAS oncogene were identified in 7 of 49 (14,3%) tumor specimens and in 2 of 11 (18,2%) hyperplasias. No correlation was found between KRAS gene mutation and age at onset, histology, grade of differentiation and clinical stage. We conclude that KRAS mutation is a relatively common event in endometrial carcinogenesis, but with no prognostic value.
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About this article
Title

Mutations of the KRAS oncogene in endometrial hyperplasia and carcinoma.

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 47, No 1 (2009)

Pages

65-68

Published online

2009-05-08

DOI

10.2478/v10042-009-0014-2

Bibliographic record

Folia Histochem Cytobiol 2009;47(1):65-68.

Authors

Bozena Dobrzycka
Sławomir J Terlikowski
Andrzej Mazurek
Oksana Kowalczuk
Wiesława Niklińska
Lech Chyczewski
Marek Kulikowski

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