Vol 47, No 3 (2009)
Original paper
Published online: 2010-02-19

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Psoriasis vulgaris and digestive system disorders: is there a linkage?

Aldona Pietrzak, Iwona Jastrzebska, Grazyna Chodorowska, Ryszard Maciejewski, Ewa Dybiec, Maria Juszkiewicz-Borowiec, Dorota Krasowska, Robert A Schwartz
DOI: 10.2478/v10042-009-0107-y
Folia Histochem Cytobiol 2009;47(3):517-524.

Abstract

Psoriasis is well-known immune-mediated skin disease often associated with co-morbidities, including dyslipidaemia and obesity. Few reports imply that the disease might be also related to pathology of mucosal surfaces, especially that of the digestive system. The authors present a case of psoriasis and concurrent digestive system abnormalities, and review the literature regarding the topic. A 40-year-old man suffered from an exacerbation of exudative psoriasis for about 6 months. Topical antipsoriatics proved ineffective and the disease gradually progressed to a severe disseminated form. Subsequent detailed examinations revealed persistent gastroduodenitis due to H. pylori infection, pancreatic dysfunction and fatty change of the liver, although the patient denied any gastrointestinal symptoms. As a result appropriate treatment of the diagnosed digestive system disorders was added to topical antipsoriatic therapy. Within 2 weeks of treatment clinical symptoms and laboratory signs showed a marked trend to normalisation. The presented medical history seems to suggest that there may be some kind of interplay between psoriasis and digestive system disorders.

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