open access

Vol 47, No 3 (2009)
ORIGINAL PAPERS
Published online: 2010-02-19
Submitted: 2011-12-19
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Inhibition of rhabdomyosarcoma's metastatic behavior through downregulation of MET receptor signaling.

Ewa Lukasiewicz, Katarzyna Miekus, Jacek Kijowski, Grazyna Drabik, Miroslawa Wilusz, Sylwia Bobis-Wozowicz, Marcin Majka
DOI: 10.2478/v10042-009-0108-x
·
Folia Histochem Cytobiol 2009;47(3):485-489.

open access

Vol 47, No 3 (2009)
ORIGINAL PAPERS
Published online: 2010-02-19
Submitted: 2011-12-19

Abstract

Rhabdomyosarcoma (RMS) is a soft tissue sarcoma usually diagnosed in children. In advanced and metastatic stages the prognosis is often poor. RMS cell lines were used for evaluation of the role of MET receptor inhibition on chemotaxis and invasion. In vivo studies were performed using NOD-SCID xenograft model. This study shows that blocking of MET expression has strong influence on metastatic behavior of RMS. MET negative cells possess a reduced potential to migrate and to invade. Downregulation of MET suppressed the ability of RMS cells to populate bone marrow. Inhibition of MET negative tumor cells engraftment into bone marrow was observed. MET negative tumors were also two to four times smaller than their wild type counterparts. Since MET receptor plays a very important role in facilitating metastasis of RMS cells, blocking of HGF-MET axis might be considered as a therapeutic option for RMS patients, at more advanced and metastatic stages.

Abstract

Rhabdomyosarcoma (RMS) is a soft tissue sarcoma usually diagnosed in children. In advanced and metastatic stages the prognosis is often poor. RMS cell lines were used for evaluation of the role of MET receptor inhibition on chemotaxis and invasion. In vivo studies were performed using NOD-SCID xenograft model. This study shows that blocking of MET expression has strong influence on metastatic behavior of RMS. MET negative cells possess a reduced potential to migrate and to invade. Downregulation of MET suppressed the ability of RMS cells to populate bone marrow. Inhibition of MET negative tumor cells engraftment into bone marrow was observed. MET negative tumors were also two to four times smaller than their wild type counterparts. Since MET receptor plays a very important role in facilitating metastasis of RMS cells, blocking of HGF-MET axis might be considered as a therapeutic option for RMS patients, at more advanced and metastatic stages.
Get Citation
About this article
Title

Inhibition of rhabdomyosarcoma's metastatic behavior through downregulation of MET receptor signaling.

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 47, No 3 (2009)

Pages

485-489

Published online

2010-02-19

DOI

10.2478/v10042-009-0108-x

Bibliographic record

Folia Histochem Cytobiol 2009;47(3):485-489.

Authors

Ewa Lukasiewicz
Katarzyna Miekus
Jacek Kijowski
Grazyna Drabik
Miroslawa Wilusz
Sylwia Bobis-Wozowicz
Marcin Majka

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