open access

Vol 47, No 3 (2009)
ORIGINAL PAPERS
Published online: 2010-02-19
Submitted: 2011-12-19
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Fluvastatin increases tyrosinase synthesis induced by UVB irradiation of B16F10 melanoma cells.

Ryszard Galus, Emir Sajjad, Justyna Niderla, Katarzyna Borowska, Krzysztof Włodarski, Paweł Włodarski, Jarosław Jóźwiak
DOI: 10.2478/v10042-008-0115-3
·
Folia Histochem Cytobiol 2009;47(3):363-365.

open access

Vol 47, No 3 (2009)
ORIGINAL PAPERS
Published online: 2010-02-19
Submitted: 2011-12-19

Abstract

Statins are widely used to lower plasma concentrations of lipids, e.g. cholesterol. One of the main effects of statin treatment is inhibition of hydroxymethyl glutaryl-coenzyme A reductase. The role of fluvastatin, a frequently used statin, was examined in potential modulation of tyrosinase (key enzyme of melanogenesis) synthesis. Levels of tyrosinase mRNA induced by UVB irradiation of B16F10 melanoma cell line were measured by real time PCR. Fluvastatin increases tyrosinase mRNA production induced by UVB irradiation in B16F10 melanoma cell line. Fluvastatin treatment may potentially influence melanin synthesis and protection against UV irradiation.

Abstract

Statins are widely used to lower plasma concentrations of lipids, e.g. cholesterol. One of the main effects of statin treatment is inhibition of hydroxymethyl glutaryl-coenzyme A reductase. The role of fluvastatin, a frequently used statin, was examined in potential modulation of tyrosinase (key enzyme of melanogenesis) synthesis. Levels of tyrosinase mRNA induced by UVB irradiation of B16F10 melanoma cell line were measured by real time PCR. Fluvastatin increases tyrosinase mRNA production induced by UVB irradiation in B16F10 melanoma cell line. Fluvastatin treatment may potentially influence melanin synthesis and protection against UV irradiation.
Get Citation
About this article
Title

Fluvastatin increases tyrosinase synthesis induced by UVB irradiation of B16F10 melanoma cells.

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 47, No 3 (2009)

Pages

363-365

Published online

2010-02-19

DOI

10.2478/v10042-008-0115-3

Bibliographic record

Folia Histochem Cytobiol 2009;47(3):363-365.

Authors

Ryszard Galus
Emir Sajjad
Justyna Niderla
Katarzyna Borowska
Krzysztof Włodarski
Paweł Włodarski
Jarosław Jóźwiak

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