open access

Vol 47, No 4 (2009)
ORIGINAL PAPERS
Published online: 2010-05-01
Submitted: 2011-12-19
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Tumor necrosis factor-alpha and its receptors in epithelial ovarian cancer.

Bozena Dobrzycka, Slawomir J Terlikowski, Magdalena Garbowicz, Wieslawa Niklińska, Piotr S Bernaczyk, Jacek Nikliński, Maciej Kinalski, Lech Chyczewski
DOI: 10.2478/v10042-008-0117-1
·
Folia Histochem Cytobiol 2009;47(4):609-613.

open access

Vol 47, No 4 (2009)
ORIGINAL PAPERS
Published online: 2010-05-01
Submitted: 2011-12-19

Abstract

The aim of the present study was to characterize the expression pattern of tumor necrosis factor (TNF)-alpha and its receptors (TNF-Rs) in the epithelial ovarian cancer (EOC) and compare these results with the outcome of 126 patients. Presence of TNF-alpha, TNFR-1 and TNFR-2 were studied by Western blotting and immunohistochemistry. The proportion of samples positive for TNF-alpha and TNF-R2 was higher in epithelial ovarian cancer patients than in benign ovarian diseases (p<0.001 and p=0.016, respectively). Immunostaining intensity of TNF-R2 were correlated with tumor stage (p<0.001) and with reduced mean survival time (MST) (p=0.002). The results of the present study suggested that tissue expression of TNF-R2 in epithelial ovarian cancer was correlated with the highest risk of cancer progression. Thus, the clinical value of activated TNF system in epithelial ovarian cancer needs to be further investigated.

Abstract

The aim of the present study was to characterize the expression pattern of tumor necrosis factor (TNF)-alpha and its receptors (TNF-Rs) in the epithelial ovarian cancer (EOC) and compare these results with the outcome of 126 patients. Presence of TNF-alpha, TNFR-1 and TNFR-2 were studied by Western blotting and immunohistochemistry. The proportion of samples positive for TNF-alpha and TNF-R2 was higher in epithelial ovarian cancer patients than in benign ovarian diseases (p<0.001 and p=0.016, respectively). Immunostaining intensity of TNF-R2 were correlated with tumor stage (p<0.001) and with reduced mean survival time (MST) (p=0.002). The results of the present study suggested that tissue expression of TNF-R2 in epithelial ovarian cancer was correlated with the highest risk of cancer progression. Thus, the clinical value of activated TNF system in epithelial ovarian cancer needs to be further investigated.
Get Citation
About this article
Title

Tumor necrosis factor-alpha and its receptors in epithelial ovarian cancer.

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 47, No 4 (2009)

Pages

609-613

Published online

2010-05-01

DOI

10.2478/v10042-008-0117-1

Bibliographic record

Folia Histochem Cytobiol 2009;47(4):609-613.

Authors

Bozena Dobrzycka
Slawomir J Terlikowski
Magdalena Garbowicz
Wieslawa Niklińska
Piotr S Bernaczyk
Jacek Nikliński
Maciej Kinalski
Lech Chyczewski

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