Tumor necrosis factor-alpha and its receptors in epithelial ovarian cancer.

Bozena Dobrzycka; Slawomir J Terlikowski; Magdalena Garbowicz; Wieslawa Niklińska; Piotr S Bernaczyk; Jacek Nikliński; Maciej Kinalski; Lech Chyczewski

doi:10.2478/v10042-008-0117-1

Vol 47, No 4 (2009)

Original paper

Submitted: 2011-12-19

Published online: 2010-05-01

View PDF

Download PDF file

Get Citation

Tumor necrosis factor-alpha and its receptors in epithelial ovarian cancer.

Bozena Dobrzycka, Slawomir J Terlikowski, Magdalena Garbowicz, Wieslawa Niklińska, Piotr S Bernaczyk, Jacek Nikliński, Maciej Kinalski, Lech Chyczewski

DOI: 10.2478/v10042-008-0117-1

Folia Histochem Cytobiol 2009;47(4):609-613.

Vol 47, No 4 (2009)

ORIGINAL PAPERS

Submitted: 2011-12-19

Published online: 2010-05-01

Abstract

The aim of the present study was to characterize the expression pattern of tumor necrosis factor (TNF)-alpha and its receptors (TNF-Rs) in the epithelial ovarian cancer (EOC) and compare these results with the outcome of 126 patients. Presence of TNF-alpha, TNFR-1 and TNFR-2 were studied by Western blotting and immunohistochemistry. The proportion of samples positive for TNF-alpha and TNF-R2 was higher in epithelial ovarian cancer patients than in benign ovarian diseases (p<0.001 and p=0.016, respectively). Immunostaining intensity of TNF-R2 were correlated with tumor stage (p<0.001) and with reduced mean survival time (MST) (p=0.002). The results of the present study suggested that tissue expression of TNF-R2 in epithelial ovarian cancer was correlated with the highest risk of cancer progression. Thus, the clinical value of activated TNF system in epithelial ovarian cancer needs to be further investigated.