open access

Vol 47, No 4 (2009)
Original paper
Submitted: 2011-12-19
Published online: 2010-05-01
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Immunohistochemical detection of prothymosin alpha in pituitary adenomas--a new marker of tumor recurrence?

Marek Pawlikowski, Katarzyna Winczyk
DOI: 10.2478/v10042-009-0096-2
·
Folia Histochem Cytobiol 2009;47(4):559-562.

open access

Vol 47, No 4 (2009)
ORIGINAL PAPERS
Submitted: 2011-12-19
Published online: 2010-05-01

Abstract

Forty pituitary adenomas were immunostained with an antibody raised against the C-terminal fragment (101-109) of human prothymosin alpha (PT alpha). The strong positive immunostaining was found in the subpopulation of cell nuclei and intratumoral vessel walls, while the cytoplasm of adenoma cells was slightly immunopositive. The significantly higher percentage of PT alpha-positive cell nuclei was found in recurrent pituitary adenomas as compared with primary tumors. However, there was no correlation between the percentage of PT alpha-positive cell nuclei and Ki-67 indices. Gonadotropinomas were characterized by higher nuclear PT alpha expression in comparison to other pituitary adenomas, which is probably linked with the high recurrence rate of these tumors. It is suggested that PT alpha immunostaining may be helpful in predicting the pituitary tumor recurrence. However, this conclusion needs to be confirmed in further prospective studies. Moreover, PT alpha may be also useful as an immunohistochemical marker of the intratumoral microvasculature.

Abstract

Forty pituitary adenomas were immunostained with an antibody raised against the C-terminal fragment (101-109) of human prothymosin alpha (PT alpha). The strong positive immunostaining was found in the subpopulation of cell nuclei and intratumoral vessel walls, while the cytoplasm of adenoma cells was slightly immunopositive. The significantly higher percentage of PT alpha-positive cell nuclei was found in recurrent pituitary adenomas as compared with primary tumors. However, there was no correlation between the percentage of PT alpha-positive cell nuclei and Ki-67 indices. Gonadotropinomas were characterized by higher nuclear PT alpha expression in comparison to other pituitary adenomas, which is probably linked with the high recurrence rate of these tumors. It is suggested that PT alpha immunostaining may be helpful in predicting the pituitary tumor recurrence. However, this conclusion needs to be confirmed in further prospective studies. Moreover, PT alpha may be also useful as an immunohistochemical marker of the intratumoral microvasculature.
Get Citation
About this article
Title

Immunohistochemical detection of prothymosin alpha in pituitary adenomas--a new marker of tumor recurrence?

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 47, No 4 (2009)

Article type

Original paper

Pages

559-562

Published online

2010-05-01

DOI

10.2478/v10042-009-0096-2

Bibliographic record

Folia Histochem Cytobiol 2009;47(4):559-562.

Authors

Marek Pawlikowski
Katarzyna Winczyk

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