open access

Vol 47, No 5 (2009)
ORIGINAL PAPERS
Published online: 2010-01-14
Submitted: 2011-12-19
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Ontogenesis of testicular function in humans.

Virginie Rouiller-Fabre, Vincent Muczynski, Romain Lambrot, Charlotte LĂŠcureuil, HervĂŠ Coffigny, Catherine Pairault, Delphine Moison, GaĂŤlle Angenard, Mariana Bakalska, Anne Marie Courtot, RenĂŠ Frydman, RenĂŠ Habert
DOI: 10.2478/v10042-009-0065-4
·
Folia Histochem Cytobiol 2009;47(5):19-24.

open access

Vol 47, No 5 (2009)
ORIGINAL PAPERS
Published online: 2010-01-14
Submitted: 2011-12-19

Abstract

The two major functions of the testis, steroidogenesis and gametogenesis, take place during fetal life. These two functions have been extensively studied in rodents and adult humans. However, their onset during fetal life is poorly documented in humans. In the first part of this work we presented both our experimental data and some data of literature concerning the development of the human fetal testis. In the second part of this article, using the organ culture system we previously developed, we have investigated the regulations or perturbations of fetal testis development both in rodent and human models. Our findings provide important insight into the potential role of exposure to environmental pollutants (physical factors, in particular ionizing radiation, cadmium and endocrine disruptors such as phthalates) during fetal testicular development and their potential deleterious effects on male fertility in adulthood. Our results highlight the specificity of the human model compared with rodent models.

Abstract

The two major functions of the testis, steroidogenesis and gametogenesis, take place during fetal life. These two functions have been extensively studied in rodents and adult humans. However, their onset during fetal life is poorly documented in humans. In the first part of this work we presented both our experimental data and some data of literature concerning the development of the human fetal testis. In the second part of this article, using the organ culture system we previously developed, we have investigated the regulations or perturbations of fetal testis development both in rodent and human models. Our findings provide important insight into the potential role of exposure to environmental pollutants (physical factors, in particular ionizing radiation, cadmium and endocrine disruptors such as phthalates) during fetal testicular development and their potential deleterious effects on male fertility in adulthood. Our results highlight the specificity of the human model compared with rodent models.
Get Citation
About this article
Title

Ontogenesis of testicular function in humans.

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 47, No 5 (2009)

Pages

19-24

Published online

2010-01-14

DOI

10.2478/v10042-009-0065-4

Bibliographic record

Folia Histochem Cytobiol 2009;47(5):19-24.

Authors

Virginie Rouiller-Fabre
Vincent Muczynski
Romain Lambrot
Charlotte LĂŠcureuil
HervĂŠ Coffigny
Catherine Pairault
Delphine Moison
GaĂŤlle Angenard
Mariana Bakalska
Anne Marie Courtot
RenĂŠ Frydman
RenĂŠ Habert

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