Vol 48, No 1 (2010)
Original paper
Submitted: 2011-12-19
Published online: 2010-06-10
Expression of the E-cadherin-catenin complex in patients with pancreatic ductal adenocarcinoma.
Anna Pryczynicz, Katarzyna Guzińska-Ustymowicz, Andrzej Kemona, Jolanta Czyzewska
DOI: 10.2478/v10042-008-0089-1
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Folia Histochem Cytobiol 2010;48(1):128-133.
Vol 48, No 1 (2010)
ORIGINAL PAPERS
Submitted: 2011-12-19
Published online: 2010-06-10
Abstract
Cadherins and catenins, mediators of intercellular interactions, play a major role in adhesion. Changes in their expression and functioning reflect invasive and metastatic properties of cancer cells. The study objective was to assess changes in the expressions of E-cadherin and alpha-, beta- and gamma-catenin proteins in pancreatic duct carcinoma in correlation with clinicopathological parameters, lymph node involvement and distant metastases. Twenty-nine patients with pancreatic duct carcinoma were analyzed in relation to gender and age, histological type, histological malignancy grade (G), local lymph node involvement and distant metastases. The expression levels of E-cadherin and alpha-, beta- and gamma-catenins were subjected to immunohistochemical labeling. Reduced expression or abnormal localization of E-cadherin and alpha-, beta- and gamma-catenins were observed in pancreatic duct carcinoma. The statistical analysis did not show any correlations of the expressions of these proteins with gender and age of patients, histological type (Hp), histological grade (G) and the presence of local lymph node involvement or distant metastases. However, correlations were found between the expression of E-cadherin and beta- catenin (p<0.001) as well of alpha-catenin with beta-catenin (p=0.006) and gamma-catenin (p=0.026). Disorders in the expression of E-cadherin reveal strong associations with abnormal expressions of alpha, beta- and gamma-catenins. Also enhanced tumor aggressiveness shows certain tendency correlations (although statistically insignificant) with the loss of E-cadherin expression and change in its localization.
Abstract
Cadherins and catenins, mediators of intercellular interactions, play a major role in adhesion. Changes in their expression and functioning reflect invasive and metastatic properties of cancer cells. The study objective was to assess changes in the expressions of E-cadherin and alpha-, beta- and gamma-catenin proteins in pancreatic duct carcinoma in correlation with clinicopathological parameters, lymph node involvement and distant metastases. Twenty-nine patients with pancreatic duct carcinoma were analyzed in relation to gender and age, histological type, histological malignancy grade (G), local lymph node involvement and distant metastases. The expression levels of E-cadherin and alpha-, beta- and gamma-catenins were subjected to immunohistochemical labeling. Reduced expression or abnormal localization of E-cadherin and alpha-, beta- and gamma-catenins were observed in pancreatic duct carcinoma. The statistical analysis did not show any correlations of the expressions of these proteins with gender and age of patients, histological type (Hp), histological grade (G) and the presence of local lymph node involvement or distant metastases. However, correlations were found between the expression of E-cadherin and beta- catenin (p<0.001) as well of alpha-catenin with beta-catenin (p=0.006) and gamma-catenin (p=0.026). Disorders in the expression of E-cadherin reveal strong associations with abnormal expressions of alpha, beta- and gamma-catenins. Also enhanced tumor aggressiveness shows certain tendency correlations (although statistically insignificant) with the loss of E-cadherin expression and change in its localization.
Title
Expression of the E-cadherin-catenin complex in patients with pancreatic ductal adenocarcinoma.
Journal
Folia Histochemica et Cytobiologica
Issue
Vol 48, No 1 (2010)
Article type
Original paper
Pages
128-133
Published online
2010-06-10
Page views
2345
Article views/downloads
2096
DOI
10.2478/v10042-008-0089-1
Bibliographic record
Folia Histochem Cytobiol 2010;48(1):128-133.
Authors
Anna Pryczynicz
Katarzyna Guzińska-Ustymowicz
Andrzej Kemona
Jolanta Czyzewska
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