open access

Vol 48, No 1 (2010)
Original paper
Submitted: 2011-12-19
Published online: 2010-06-10
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Correlation between hepatocyte growth factor receptor and vascular endothelial growth factor-A in breast carcinoma.

Iwona Gisterek, Rafał Matkowski, Elzbieta Suder, Agnieszka Hałoń, Jolanta Szelachowska, Ewelina Łata, Aleksandra Łacko, Przemysław Biecek, Jan Kornafel
DOI: 10.2478/v10042-010-0016-0
·
Folia Histochem Cytobiol 2010;48(1):78-83.

open access

Vol 48, No 1 (2010)
ORIGINAL PAPERS
Submitted: 2011-12-19
Published online: 2010-06-10

Abstract

The aim of the study was to evaluate the prognostic value of the vascular endothelial growth factor A (VEGF-A) and hepatocyte growth factor receptor (HGFR, c-met) expressions in homogenous group of breast cancer patients. Tumor samples were collected from 98 patients with invasive ductal breast carcinoma stage II treated with primary surgery. We have observed a strong correlation between VEGF-A and c-met. No correlations were found between VEGF-A or HGFR expressions and clinical parameters (tumor size, grade, axillary lymph node status, age), 5- and 10-years DFS or OS. Our study did not reveal any prognostic value of c-met or VEGF. In addition they are not useful to separate a patients' subgroup with poor prognosis. Unlike in other authors' studies, our patients' group is very homogenous which might tribute to obtained results.

Abstract

The aim of the study was to evaluate the prognostic value of the vascular endothelial growth factor A (VEGF-A) and hepatocyte growth factor receptor (HGFR, c-met) expressions in homogenous group of breast cancer patients. Tumor samples were collected from 98 patients with invasive ductal breast carcinoma stage II treated with primary surgery. We have observed a strong correlation between VEGF-A and c-met. No correlations were found between VEGF-A or HGFR expressions and clinical parameters (tumor size, grade, axillary lymph node status, age), 5- and 10-years DFS or OS. Our study did not reveal any prognostic value of c-met or VEGF. In addition they are not useful to separate a patients' subgroup with poor prognosis. Unlike in other authors' studies, our patients' group is very homogenous which might tribute to obtained results.
Get Citation
About this article
Title

Correlation between hepatocyte growth factor receptor and vascular endothelial growth factor-A in breast carcinoma.

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 48, No 1 (2010)

Article type

Original paper

Pages

78-83

Published online

2010-06-10

DOI

10.2478/v10042-010-0016-0

Bibliographic record

Folia Histochem Cytobiol 2010;48(1):78-83.

Authors

Iwona Gisterek
Rafał Matkowski
Elzbieta Suder
Agnieszka Hałoń
Jolanta Szelachowska
Ewelina Łata
Aleksandra Łacko
Przemysław Biecek
Jan Kornafel

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