open access

Vol 48, No 2 (2010)
Original paper
Published online: 2010-08-03
Submitted: 2011-12-19
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Pathological findings in cornea tissue of patients with penetrating keratoplasty.

Helga KostelnĂĄ, JĂĄn Rosocha, Edita PaulĂ­ kovĂĄ, Igor KozĂĄk, MĂĄria AntalovĂĄ, Martin Mahel, Denisa HarvanovĂĄ, JozefĂ­na PetrovicovĂĄ, Ladislav BobĂĄk
DOI: 10.2478/v10042-010-0002-6
·
Folia Histochem Cytobiol 2010;48(2):267-272.

open access

Vol 48, No 2 (2010)
ORIGINAL PAPERS
Published online: 2010-08-03
Submitted: 2011-12-19

Abstract

The aim of this clinical study was to examine corneas extracted from the patients during penetrating keratoplasty for the presence of immunoglobulins and inflammatory cells that can be warning for the graft failure. Individual clinical diagnoses were correlated to the presence of the inflammatory signs in corneal tissue. The signs of inflammation in corneal layers were detected especially in group of patients classified as viral keratitis but were also found in corneas of patients with degenerative diseases of the cornea. Depending on the number of keratoplasties no statistical difference in analysed parameters was found. Inflammatory process represented by slight positive presence cellular infiltration and/or immunoglobulins could be present in corneal tissue also in absence of acute manifestation. Histological and immunohistochemical evaluation of corneal tissue from patients undergoing penetrating keratoplasty could improve estimation of correct diagnosis. Subsequently prompt adequate therapy could improve worse prognosis of corneal graft with evident immune process.

Abstract

The aim of this clinical study was to examine corneas extracted from the patients during penetrating keratoplasty for the presence of immunoglobulins and inflammatory cells that can be warning for the graft failure. Individual clinical diagnoses were correlated to the presence of the inflammatory signs in corneal tissue. The signs of inflammation in corneal layers were detected especially in group of patients classified as viral keratitis but were also found in corneas of patients with degenerative diseases of the cornea. Depending on the number of keratoplasties no statistical difference in analysed parameters was found. Inflammatory process represented by slight positive presence cellular infiltration and/or immunoglobulins could be present in corneal tissue also in absence of acute manifestation. Histological and immunohistochemical evaluation of corneal tissue from patients undergoing penetrating keratoplasty could improve estimation of correct diagnosis. Subsequently prompt adequate therapy could improve worse prognosis of corneal graft with evident immune process.
Get Citation
About this article
Title

Pathological findings in cornea tissue of patients with penetrating keratoplasty.

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 48, No 2 (2010)

Article type

Original paper

Pages

267-272

Published online

2010-08-03

DOI

10.2478/v10042-010-0002-6

Bibliographic record

Folia Histochem Cytobiol 2010;48(2):267-272.

Authors

Helga KostelnĂĄ
JĂĄn Rosocha
Edita PaulĂ­ kovĂĄ
Igor KozĂĄk
MĂĄria AntalovĂĄ
Martin Mahel
Denisa HarvanovĂĄ
JozefĂ­na PetrovicovĂĄ
Ladislav BobĂĄk

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