open access

Vol 48, No 2 (2010)
ORIGINAL PAPERS
Published online: 2010-08-03
Submitted: 2011-12-19
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Evaluation of distant results after lamivudine discontinuation in children with chronic hepatitis B.

Joanna Pancewicz, Oksana Kowalczuk, Lech Chyczewski
DOI: 10.2478/v10042-08-0107-3
·
Folia Histochem Cytobiol 2010;48(2):237-241.

open access

Vol 48, No 2 (2010)
ORIGINAL PAPERS
Published online: 2010-08-03
Submitted: 2011-12-19

Abstract

The aim of this study was to estimate distant results after discontinuation of long term lamivudine treatment in children with chronic hepatitis B. Furthermore, the emergence of HBV polymerase gene variants in YMDD motif during therapy was examined. Additionally, the most commonly occurring type of mutation in the polymerase YMDD region were investigated. The study involved 27 HBeAg positive children with chronic hepatitis B. Children included to lamivudine therapy were previously treated without effects with interferon alpha.

Abstract

The aim of this study was to estimate distant results after discontinuation of long term lamivudine treatment in children with chronic hepatitis B. Furthermore, the emergence of HBV polymerase gene variants in YMDD motif during therapy was examined. Additionally, the most commonly occurring type of mutation in the polymerase YMDD region were investigated. The study involved 27 HBeAg positive children with chronic hepatitis B. Children included to lamivudine therapy were previously treated without effects with interferon alpha.
Get Citation
About this article
Title

Evaluation of distant results after lamivudine discontinuation in children with chronic hepatitis B.

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 48, No 2 (2010)

Pages

237-241

Published online

2010-08-03

DOI

10.2478/v10042-08-0107-3

Bibliographic record

Folia Histochem Cytobiol 2010;48(2):237-241.

Authors

Joanna Pancewicz
Oksana Kowalczuk
Lech Chyczewski

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