open access
Vol 48, No 2 (2010)
Original paper
Submitted: 2011-12-19
Published online: 2010-08-03
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Evaluation of distant results after lamivudine discontinuation in children with chronic hepatitis B.
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DOI: 10.2478/v10042-08-0107-3
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Folia Histochem Cytobiol 2010;48(2):237-241.
open access
Vol 48, No 2 (2010)
ORIGINAL PAPERS
Submitted: 2011-12-19
Published online: 2010-08-03
Abstract
The aim of this study was to estimate distant results after discontinuation of long term lamivudine treatment in children with chronic hepatitis B. Furthermore, the emergence of HBV polymerase gene variants in YMDD motif during therapy was examined. Additionally, the most commonly occurring type of mutation in the polymerase YMDD region were investigated. The study involved 27 HBeAg positive children with chronic hepatitis B. Children included to lamivudine therapy were previously treated without effects with interferon alpha.
Abstract
The aim of this study was to estimate distant results after discontinuation of long term lamivudine treatment in children with chronic hepatitis B. Furthermore, the emergence of HBV polymerase gene variants in YMDD motif during therapy was examined. Additionally, the most commonly occurring type of mutation in the polymerase YMDD region were investigated. The study involved 27 HBeAg positive children with chronic hepatitis B. Children included to lamivudine therapy were previously treated without effects with interferon alpha.
Get Citation
About this articleTitle
Evaluation of distant results after lamivudine discontinuation in children with chronic hepatitis B.
Journal
Folia Histochemica et Cytobiologica
Issue
Article type
Original paper
Pages
237-241
Published online
2010-08-03
Page views
2081
Article views/downloads
1630
DOI
10.2478/v10042-08-0107-3
Bibliographic record
Folia Histochem Cytobiol 2010;48(2):237-241.
Authors
Joanna Pancewicz
Oksana Kowalczuk
Lech Chyczewski
