Vol 48, No 3 (2010)
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Published online: 2010-11-13

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Total matrix metalloproteinase-8 serum levels in patients labouring preterm and patients with threatened preterm delivery.

Paweł Kuć, Adam Lemancewicz, Piotr Laudański, Małgorzata Krętowska, Tadeusz Laudański
DOI: 10.2478/v10042-010-0037-8
Folia Histochem Cytobiol 2010;48(3):366-370.


Preterm labour and prematurity are still a main cause of perinatal morbidity nowadays. The aim of our study was to assess the role of MMP-8 as a predictive marker of preterm delivery. Four groups of patients were involved to the study: I - pregnant women at 24-34 weeks of gestation with any symptoms of threatened preterm labour; II - threatened preterm labour patients between 24-34 weeks of gestation; III - preterm vaginal delivery patients; IV - healthy term vaginal delivery patients. Serum concentration of total MMP-8 was measured using two enzyme-linked immunosorbent assays. There were no significant differences in the median concentrations of total MMP-8 between physiological pregnancy and threatened preterm labour patients with existing uterine contractility. No significant differences of total MMP-8 were either found between healthy term and preterm labouring patients. The studies on a larger population are needed to reject the hypothesis that preterm labour is connected with increased MMP-8 plasma concentrations of women in preterm labour and threatened preterm delivery.

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Folia Histochemica et Cytobiologica