Evaluation of TLR4 expression and chosen parameters of oxidative-antioxidative balance in young children with food allergy.

Barbara Kamer; Karolina Kulig; Przemysław Lewkowicz; Anna Kamer-Bartosińska; Henryk Tchórzewski

doi:10.2478/v10042-010-0068-1

Vol 48, No 3 (2010)

Original paper

Submitted: 2011-12-19

Published online: 2010-11-13

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Evaluation of TLR4 expression and chosen parameters of oxidative-antioxidative balance in young children with food allergy.

Barbara Kamer, Karolina Kulig, Przemysław Lewkowicz, Anna Kamer-Bartosińska, Henryk Tchórzewski

DOI: 10.2478/v10042-010-0068-1

Folia Histochem Cytobiol 2010;48(3):346-350.

Vol 48, No 3 (2010)

ORIGINAL PAPERS

Submitted: 2011-12-19

Published online: 2010-11-13

Abstract

The authors evaluated mRNA TLR4 expression on neutrophils and the chosen parameters of oxidative-antioxidative balance in blood of 35 children with food allergy (17 of them with IgE-dependent allergy and 18 with IgE-independent allergy) and 15 healthy children without any allergy. The age of these children ranged from 1 to 36 months. Children with food allergy in comparison with healthy children were found to have lower mRNA TLR4 expression, higher average value of chemiluminescence (CL) and its increase after stimulation by fMLP, PMA and OZ as well as lower TAS values. Disturbances of oxidative-antioxidative balance were found in children with food allergy. We suggest that natural immunity is involved in the development of food allergy mechanisms. Moreover, chemiluminescence can be used as an additional diagnostic test.