open access

Vol 48, No 3 (2010)
ORIGINAL PAPERS
Published online: 2010-11-13
Submitted: 2011-12-19
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Evaluation of TLR4 expression and chosen parameters of oxidative-antioxidative balance in young children with food allergy.

Barbara Kamer, Karolina Kulig, Przemysław Lewkowicz, Anna Kamer-Bartosińska, Henryk Tchórzewski
DOI: 10.2478/v10042-010-0068-1
·
Folia Histochem Cytobiol 2010;48(3):346-350.

open access

Vol 48, No 3 (2010)
ORIGINAL PAPERS
Published online: 2010-11-13
Submitted: 2011-12-19

Abstract

The authors evaluated mRNA TLR4 expression on neutrophils and the chosen parameters of oxidative-antioxidative balance in blood of 35 children with food allergy (17 of them with IgE-dependent allergy and 18 with IgE-independent allergy) and 15 healthy children without any allergy. The age of these children ranged from 1 to 36 months. Children with food allergy in comparison with healthy children were found to have lower mRNA TLR4 expression, higher average value of chemiluminescence (CL) and its increase after stimulation by fMLP, PMA and OZ as well as lower TAS values. Disturbances of oxidative-antioxidative balance were found in children with food allergy. We suggest that natural immunity is involved in the development of food allergy mechanisms. Moreover, chemiluminescence can be used as an additional diagnostic test.

Abstract

The authors evaluated mRNA TLR4 expression on neutrophils and the chosen parameters of oxidative-antioxidative balance in blood of 35 children with food allergy (17 of them with IgE-dependent allergy and 18 with IgE-independent allergy) and 15 healthy children without any allergy. The age of these children ranged from 1 to 36 months. Children with food allergy in comparison with healthy children were found to have lower mRNA TLR4 expression, higher average value of chemiluminescence (CL) and its increase after stimulation by fMLP, PMA and OZ as well as lower TAS values. Disturbances of oxidative-antioxidative balance were found in children with food allergy. We suggest that natural immunity is involved in the development of food allergy mechanisms. Moreover, chemiluminescence can be used as an additional diagnostic test.
Get Citation
About this article
Title

Evaluation of TLR4 expression and chosen parameters of oxidative-antioxidative balance in young children with food allergy.

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 48, No 3 (2010)

Pages

346-350

Published online

2010-11-13

DOI

10.2478/v10042-010-0068-1

Bibliographic record

Folia Histochem Cytobiol 2010;48(3):346-350.

Authors

Barbara Kamer
Karolina Kulig
Przemysław Lewkowicz
Anna Kamer-Bartosińska
Henryk Tchórzewski

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