Cysteine peptidases and their inhibitors in breast and genital cancer.

Anil Kumar Agrawal; Godwin Bwire Ekonjo; Elżbieta Teterycz; Dorota Zyoeko; Zygmunt Grzebieniak; Magdalena Milan; Grzegorz Marek; Maciej Siewiński

doi:10.2478/v10042-10-0067-2

Vol 48, No 3 (2010)

Original paper

Submitted: 2011-12-19

Published online: 2010-11-13

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Cysteine peptidases and their inhibitors in breast and genital cancer.

Anil Kumar Agrawal, Godwin Bwire Ekonjo, Elżbieta Teterycz, Dorota Zyoeko, Zygmunt Grzebieniak, Magdalena Milan, Grzegorz Marek, Maciej Siewiński

DOI: 10.2478/v10042-10-0067-2

Folia Histochem Cytobiol 2010;48(3):323-327.

Vol 48, No 3 (2010)

ORIGINAL PAPERS

Submitted: 2011-12-19

Published online: 2010-11-13

Abstract

Cysteine proteinases and their inhibitors probably play the main role in carcinogenesis and metastasis. The metastasis process need external proteolytic activities that pass several barriers which are membranous structures of the connective tissue which includes, the basement membrane of blood vessels. Activities of the proteinases are regulated by endogenous inhibitors and activators. The imbalance between cysteine proteinases and cystatins seems to be associated with an increase in metastatic potential in some tumors. It has also been reported that proteinase inhibitors, specific antibodies for these enzymes and inhibition of the urokinase receptor may prevent cancer cell invasion. Some proteinase inhibitor could serve as agents for cancer treatment.