open access

Vol 48, No 3 (2010)
ORIGINAL PAPERS
Published online: 2010-11-13
Submitted: 2011-12-19
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Cysteine peptidases and their inhibitors in breast and genital cancer.

Anil Kumar Agrawal, Godwin Bwire Ekonjo, Elżbieta Teterycz, Dorota Zyoeko, Zygmunt Grzebieniak, Magdalena Milan, Grzegorz Marek, Maciej Siewiński
DOI: 10.2478/v10042-10-0067-2
·
Folia Histochem Cytobiol 2010;48(3):323-327.

open access

Vol 48, No 3 (2010)
ORIGINAL PAPERS
Published online: 2010-11-13
Submitted: 2011-12-19

Abstract

Cysteine proteinases and their inhibitors probably play the main role in carcinogenesis and metastasis. The metastasis process need external proteolytic activities that pass several barriers which are membranous structures of the connective tissue which includes, the basement membrane of blood vessels. Activities of the proteinases are regulated by endogenous inhibitors and activators. The imbalance between cysteine proteinases and cystatins seems to be associated with an increase in metastatic potential in some tumors. It has also been reported that proteinase inhibitors, specific antibodies for these enzymes and inhibition of the urokinase receptor may prevent cancer cell invasion. Some proteinase inhibitor could serve as agents for cancer treatment.

Abstract

Cysteine proteinases and their inhibitors probably play the main role in carcinogenesis and metastasis. The metastasis process need external proteolytic activities that pass several barriers which are membranous structures of the connective tissue which includes, the basement membrane of blood vessels. Activities of the proteinases are regulated by endogenous inhibitors and activators. The imbalance between cysteine proteinases and cystatins seems to be associated with an increase in metastatic potential in some tumors. It has also been reported that proteinase inhibitors, specific antibodies for these enzymes and inhibition of the urokinase receptor may prevent cancer cell invasion. Some proteinase inhibitor could serve as agents for cancer treatment.
Get Citation
About this article
Title

Cysteine peptidases and their inhibitors in breast and genital cancer.

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 48, No 3 (2010)

Pages

323-327

Published online

2010-11-13

DOI

10.2478/v10042-10-0067-2

Bibliographic record

Folia Histochem Cytobiol 2010;48(3):323-327.

Authors

Anil Kumar Agrawal
Godwin Bwire Ekonjo
Elżbieta Teterycz
Dorota Zyoeko
Zygmunt Grzebieniak
Magdalena Milan
Grzegorz Marek
Maciej Siewiński

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