open access

Vol 48, No 4 (2010)
ORIGINAL PAPERS
Published online: 2011-04-12
Submitted: 2011-12-19
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Molecular differences in the KRAS gene mutation between a primary tumor and related metastatic sites - case report and a literature review.

Ewa Anna Kosakowska, Rafał Stec, Radosław Charkiewicz, Marta Skoczek, Lech Chyczewski
DOI: 10.2478/v10042-010-0078-z
·
Folia Histochem Cytobiol 2010;48(4):597-602.

open access

Vol 48, No 4 (2010)
ORIGINAL PAPERS
Published online: 2011-04-12
Submitted: 2011-12-19

Abstract

In recent years the the set of diagnostic tools in colorectal cancers has been extended by the assessment of the KRAS gene status. Currently it is a necessary step in order to qualify patients for the targeted therapy. The results of the analysis of several studies revealed a high rate of compliance of the KRAS gene mutational status in primary and metastatic tumors. In this paper we present a rare case of incompatibility of the KRAS mutations in the primary tumor located in the colon and metastatic changes in the liver.

Abstract

In recent years the the set of diagnostic tools in colorectal cancers has been extended by the assessment of the KRAS gene status. Currently it is a necessary step in order to qualify patients for the targeted therapy. The results of the analysis of several studies revealed a high rate of compliance of the KRAS gene mutational status in primary and metastatic tumors. In this paper we present a rare case of incompatibility of the KRAS mutations in the primary tumor located in the colon and metastatic changes in the liver.
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About this article
Title

Molecular differences in the KRAS gene mutation between a primary tumor and related metastatic sites - case report and a literature review.

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 48, No 4 (2010)

Pages

597-602

Published online

2011-04-12

DOI

10.2478/v10042-010-0078-z

Bibliographic record

Folia Histochem Cytobiol 2010;48(4):597-602.

Authors

Ewa Anna Kosakowska
Rafał Stec
Radosław Charkiewicz
Marta Skoczek
Lech Chyczewski

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