Vol 48, No 4 (2010)
Original paper
Published online: 2011-04-12
Molecular differences in the KRAS gene mutation between a primary tumor and related metastatic sites - case report and a literature review.
DOI: 10.2478/v10042-010-0078-z
Folia Histochem Cytobiol 2010;48(4):597-602.
Abstract
In recent years the the set of diagnostic tools in colorectal cancers has been extended by the assessment of the KRAS gene status. Currently it is a necessary step in order to qualify patients for the targeted therapy. The results of the analysis of several studies revealed a high rate of compliance of the KRAS gene mutational status in primary and metastatic tumors. In this paper we present a rare case of incompatibility of the KRAS mutations in the primary tumor located in the colon and metastatic changes in the liver.
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