Inhibition of cysteine peptidase activity in ascitic fluid in pancreatic cancer patients.

Anil Kumar Agrawal; Wojciech Kielan; Abdo Katib; Zgmunt Grzebieniak; Adam Skalski; Tomasz Grzebieniak; Lukasz Duda-Barcik; Anna Janocha; Maciej Siewiński

doi:10.2478/v10042-010-0057-4

Vol 48, No 4 (2010)

Original paper

Published online: 2011-04-12

Submitted: 2011-12-19

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Inhibition of cysteine peptidase activity in ascitic fluid in pancreatic cancer patients.

Anil Kumar Agrawal, Wojciech Kielan, Abdo Katib, Zgmunt Grzebieniak, Adam Skalski, Tomasz Grzebieniak, Lukasz Duda-Barcik, Anna Janocha, Maciej Siewiński

DOI: 10.2478/v10042-010-0057-4

Folia Histochem Cytobiol 2010;48(4):513-517.

Vol 48, No 4 (2010)

ORIGINAL PAPERS

Published online: 2011-04-12

Submitted: 2011-12-19

Abstract

The work's objective is to answer the question whether there is any possibility of activity inhibition of cysteine peptidases inhibitors playing an important role in key processes accompanying cancer formation, including pancreas. There is a justified speculation that specific inhibitors of these enzymes may inhibit development of cancer processes by inhibiting their activity. In vitro studies confirmed that these enzymes in ascitic fluid were inhibited with egg whites inhibitors even to 90% of their original activity.